146500-06-3Relevant articles and documents
Potent HIV-1 Protease Inhibitors: Stereoselective Synthesis of a Dipeptide Mimic
Ghosh, Arun K.,McKee, Sean P.,Thompson, Wayne J.,Darke, Paul L.,Zugay, Joan C.
, p. 1025 - 1029 (1993)
The synthesis of a differentially protected dipeptide mimic 10 in enantiomerically pure form is described.The key step involves the epimerization of the C-2 center of the lactone 4, hydrolysis and protection of the resulting hydroxy acid, followed by Curt