98818-50-9

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 98818-44-1 (2S,4S,5S)-2-Benzyl-5-tert-butoxycarbonylamino-4-hydroxy-6-phenyl-hexanoic acid 
• 98818-42-9 (3S,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one 
• 620-05-3 iodomethylbenzene 
• 133333-27-4 tert-butyl (1S)-1-[(2S)-5-oxotetrahydrofuran-2-yl]-2-phenylethylcarbamate 
• 98818-41-8 (3R,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one 

Downstream Products

• 146500-06-3 (2S,4S,5S)-2-<<(phenylmethoxy)carbonyl>amino>-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-5-<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenylhexane 
• 144163-88-2 ((1S,2S,4S)-4-amino-1-benzyl-2-hydroxy-5-phenyl-pentyl)-carbamic acid tert-butyl ester 
• 146500-15-4 ((1S,3S,4S)-4-Amino-1-benzyl-3-hydroxy-5-phenyl-pentyl)-carbamic acid benzyl ester 
• 144164-55-6 di(tert-butyl) N,N'-((2S,5S)-3-oxo-1,6-diphenylhexane-2,5-diyl)dicarbamate 
• 146500-09-6 (2S,4S,5S)-2-<<(phenylmethoxy)carbonyl>amino>-5-<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenyl-4-hydroxyhexane 
• 144141-82-2 (2S,4S,5S)-2,5-bis<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenyl-4-hydroxyhexane 
• 210224-11-6 (S)-4-[(2S,4S,5S)-2-Benzyl-5-tert-butoxycarbonylamino-4-(tert-butyl-dimethyl-silanyloxy)-6-phenyl-hexanoylamino]-4-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-butyric acid benzyl ester 
• 210224-07-0 {(1S,2S,4S)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-[(S)-3-carbamoyl-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-propylcarbamoyl]-5-phenyl-pentyl}-carbamic acid tert-butyl ester 
• 210224-15-0 {(1S,2S,4S)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-[(1S,2S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-methyl-butylcarbamoyl]-5-phenyl-pentyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Peptide inhibitors of aspartic proteinases with hydroxyethylene isostere replacement of peptide bond. II. Preparation of pseudotetrapeptides derived from diastereoisomeric 5-amino-2-benzyl-4-hydroxy-6-phenylhexanoic acids

Twelve pseudotetrapeptides, Boc-NHCH(CH2Ph)CH(OH)CH2CH(CH2Ph) CO-Xaa-Phe-NH2 9-11, were prepared by [(benzotriazol-1-yl)oxy]tris(dimethylamino)phosphonium hexafluorophosphatemediated couplings of diastereoisomer

Potent HIV-1 Protease Inhibitors: Stereoselective Synthesis of a Dipeptide Mimic

The synthesis of a differentially protected dipeptide mimic 10 in enantiomerically pure form is described.The key step involves the epimerization of the C-2 center of the lactone 4, hydrolysis and protection of the resulting hydroxy acid, followed by Curt

Dipeptide Isosteres. 2. Synthesis of Hydroxyethylene Dipeptide Isostere Diastereomers From a Common γ-Lactone Intermediate. Preparation of Renin and HIV-1 Protease Inhibitor Transition State Mimics.

A general strategy for the synthesis of the hydroxyethylene dipeptide isostere diastereomers C or D has been developed.The syntheses proceeded through a common γ-lactone intermediate A or B.The C(3α)γ-lactone diastereomer A was prepared from the N-Cbz pro