98818-42-9

Basic information

• Product Name: (3S,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one
• Synonyms: (3S,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one
• CAS NO: 98818-42-9
• Molecular Weight: 395.499
• Mol File: 98818-42-9.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (3S,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one(98818-42-9)
• EPA Substance Registry System: (3S,5S)-3-benzyl-5-{(1S)-1-[(tert-butoxycarbonyl)amino]-2-phenylethyl}dihydrofuran-2-(3H)-one(98818-42-9)

Safety Data

• Hazardous Substances Data: 98818-42-9(Hazardous Substances Data)

Upstream product

• 591-51-5 phenyllithium 
• 104293-40-5 (5S,1'S)-5-<1-<<(tert-butyloxy)carbonyl>amino>-2-phenylethyl>-3-methylenedihydrofuran-2(4H)-one 
• 100-39-0 benzyl bromide 
• 133333-27-4 tert-butyl (1S)-1-[(2S)-5-oxotetrahydrofuran-2-yl]-2-phenylethylcarbamate 
• 146500-14-3 [(S)-1-((S)-4-Benzyl-5-oxo-2,5-dihydro-furan-2-yl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 620-05-3 iodomethylbenzene 
• 14131-84-1 2,3:5,6-di-O-isopropylidene-α-D-mannofuranose 
• 137038-63-2 deux références: JFP452-1 et JFP456b 
• 137007-30-8 (R)-1-((S)-5-Methoxy-tetrahydro-furan-2-yl)-2-phenyl-ethanol 
• 137007-25-1 (R)-4-((S)-5-Methoxy-2,5-dihydro-furan-2-yl)-2,2-dimethyl-[1,3]dioxolane 
• 61845-17-8 methyl D-2,3-dideoxyglucofuranoside 
• 137007-28-4 (S)-2-Methoxy-5-(R)-oxiranyl-tetrahydro-furan 
• 68144-11-6 1,4-anhydro-2-deoxy-5,6-O-isopropylidene-D-arabinohex-1-enitol 
• 530-26-7 D-Mannose 

Downstream Products

• 144141-82-2 (2S,4S,5S)-2,5-bis<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenyl-4-hydroxyhexane 
• 146500-06-3 (2S,4S,5S)-2-<<(phenylmethoxy)carbonyl>amino>-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-5-<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenylhexane 
• 146500-09-6 (2S,4S,5S)-2-<<(phenylmethoxy)carbonyl>amino>-5-<<(1,1-dimethylethoxy)carbonyl>amino>-1,6-diphenyl-4-hydroxyhexane 
• 144164-55-6 di(tert-butyl) N,N'-((2S,5S)-3-oxo-1,6-diphenylhexane-2,5-diyl)dicarbamate 
• 146500-15-4 ((1S,3S,4S)-4-Amino-1-benzyl-3-hydroxy-5-phenyl-pentyl)-carbamic acid benzyl ester 
• 144163-88-2 ((1S,2S,4S)-4-amino-1-benzyl-2-hydroxy-5-phenyl-pentyl)-carbamic acid tert-butyl ester 
• 98818-50-9 (2S,4S,5S)-5-{[(1,1-dimethylethoxy)carbonyl]amino}-4-{[(1,1-dimethylethyl)dimethylsilyl]oxy}-6-phenyl-2-(phenylmethyl)hexanoic acid 
• 147912-04-7 [(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-carbamic acid tert-butyl ester 
• 126456-36-8 L-685434 
• 126410-32-0 {(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-[(S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-5-phenyl-pentyl}-carbamic acid tert-butyl ester 
• 126409-24-3 {(1S)-benzyl-(4R)-[1-((1S)-carbamoyl-2-phenyl-ethylcarbamoyl)-(1S)-3-methyl-butyl-carbamoyl]-(2S)-hydroxy-5-phenyl-pentyl} carbamic acid tert-butyl ester 
• 98818-48-5 C₃₆H₅₉NO₅Si₂ 
• 98818-51-0 N-(1,1-dimethylethoxycarbonyl)-5(S)-amino-4(S)-(t-butyldimethylsilyloxy)-6-phenyl-2(R)-(phenylmethyl)hexanoic acid 
• 98818-45-2 5(S)-(Boc-amino)-4(S)-hydroxy-6-phenyl-2(R)-phenylmethylhexanoic acid 

Relevant articles and documents

Application of the asymmetric aminohydroxylation reaction for the syntheses of HIV-protease inhibitor, hydroxyethylene dipeptide isostere and γ-amino acid derivative

An enantioselective synthesis of lactone 1, a precursor to the (2R,4S,5S) hydroxyethylene dipeptide isostere and amino acid AHPPA 2 has been accomplished from the common intermediate 5 employing Sharpless asymmetric aminohydroxylation as the key step.

Short total synthesis of aspartyl protease inhibitors L-685,434, L-682,679 and L-685,458

Hydroxyethylene dipeptide isosteres L-685,434, L-682,679 and L-685,458 were synthesized in a few steps by a sequence involving an allyltrichlorostannane coupling with an α-aminoaldehyde followed by hydroboration of the corresponding 1,2-syn and 1,2-anti a

5-amino-4-hydroxyhexanoic acid derivatives

Compounds of formula I STR1 or their hydroxy-protected derivatives, and compounds of formula I' STR2 wherein T is an acyl radical of formula Z STR3 wherein Rz is unsubstituted or substituted hydrocarbyl wherein at least one carbon atom has been replaced by a hetero atom with the proviso that a hetero atom is not bonded directly to the carbonyl to which the radical Rz is bonded, alkyl having two or more carbon atoms, lower alkenyl, lower alkynyl, aryl or unsubstituted or substituted amino, and wherein the radicals R1, B1, R2, R3, A1, A2 and NR4 R5 are as defined in the description, and precursors thereof, are described. The compounds have pharmaceutical activity, for example in the treatment of retroviral diseases, such as AIDS.