144256-13-3Relevant academic research and scientific papers
Copper-catalyzed domino route to natural nostoclides and analogues: A total synthesis of nostoclides i and II
Ngi, Samuel Inack,Petrignet, Julien,Duwald, Romain,El Hilali, El Mostafa,Abarbri, Mohamed,Duchêne, Alain,Thibonnet, Jér?me
, p. 2936 - 2941 (2014/03/21)
An original and convenient domino route to natural nostoclides I and II has been developed using a two-step sequence consisting of a copper-cat-alyzed tandem reaction associated with Suzuki cross-coupling. The methodology employed for this total synthesis appeared to be an interesting and suffi-ciently flexible tool to allow the synthesis of numer-ous analogues of these nostoclides.
Synthesis of 4-(2,2-dibromovinyl)phenol and its one-pot esterification
Zhang, Wensheng,Xu, Wenjing,Zhang, Fei,Li, Jitao,Liu, Mei,Li, Wei
experimental part, p. 957 - 964 (2012/08/27)
In situ treatment of 4-(2,2-dibromovinyl)phenol, which was prepared from 4-hydroxybenzaldehyde and carbon tetrabromide in CH2Cl2 under Corey-Fuchs conditions, with a diverse range of acids in the presence of dicyclohexyl-carbodiimide
"Click chemistry" as a versatile route to synthesize and modulate bent-core liquid crystalline materials
Gimeno, Nelida,Martin-Rapun, Rafael,Rodriguez-Conde, Sofia,Serrano, Jose Luis,Folcia, Cesar L.,Pericas, Miquel A.,Ros, M. Blanca
supporting information, p. 16791 - 16800 (2012/10/30)
Three series of bent-shaped compounds containing the 1,2,3-triazole ring in the central core of the molecule have been prepared by the most extended "click chemistry" reaction, the copper-catalyzed azide-alkyne cycloaddition (CuAAC). This research demonstrates the versatility of this synthetic approach with the aim of achieving innovative compact supramolecular organizations. The appropriate combination of the 1,2,3-triazole synthon linked either to a methylene unit (series M) or to a methylenoxycarbonyl block (series MC) has allowed the induction of a variety of non-classical bent-core liquid crystal phases versus the classic mesophases promoted by 1,4-diphenyl-1,2,3- triazole derivatives (series T). Through a suitable selection of common lateral structures connected by "click chemistry" both the transition temperatures and mesomorphism, ranging from lamellar to columnar or B4-like supramolecular liquid crystalline organizations, can be tuned. The Royal Society of Chemistry 2012.
METHOXYIMINO COMPOUNDS AND FUNGICIDE COMPOSITION COMPRISING SAME
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Page/Page column 17-18, (2009/07/17)
The present invention provides a methoxyimino compound, and a fungicide composition comprising same as an active ingredient. The methoxyimino compound of the present invention, which has an excellent antifungal activity against a wide spectrum of fungi even at a low application rate, can be used to protect various crops.
3α-Hydroxy-3β-(phenylethynyl)-5β-pregnan-20-ones: Synthesis and pharmacological activity of neuroactive steroids with high affinity for GABA(A) receptors
Upasani, Ravindra B.,Yang, Kevin C.,Acosta-Burruel, Manuel,Konkoy, Chris S.,McLellan, James A.,Woodward, Richard M.,Lan, Nancy C.,Carter, Richard B.,Hawkinson, Jon E.
, p. 73 - 84 (2007/10/03)
Neuroactive steroids that allosterically modulate GABA(A) receptors have potential uses as anticonvulsants, anxiolytics, and sedative-hypnotic agents. Recently, a series of pregnanes substituted with simple alkyl groups at the 3β-position were synthesized
Development of a highly cardioselective ultra short-acting β-blocker, ONO-1101
Iguchi,Iwamura,Nishizaki,Hayashi,Senokuchi,Kobayashi,Sakaki,Hachiya,Ichioka,Kawamura
, p. 1462 - 1469 (2007/10/02)
A novel, highly cardioselective ultra short-acting β-blocker, ONO-1101, has been developed for application in the emergency treatment of tachycardia and better control of heart rate in surgery. This agent is approximately nine times more potent in β-blocking activity in vivo and eight times more cardioselective in vitro than esmolol. This β-blocking drug has a short duration of activity, enabling rapid recovery after cessation of administration if side effects occur. It can be used safely in patients suffering from acute heart disease and represents a major therapeutic advance in the treatment of heart disease.
