78589-65-8

Upstream product

• 78589-64-7 3-(4-Acetoxy-phenyl)-propynoic acid methyl ester 
• 7400-08-0 p-Coumaric Acid 
• 60512-57-4 1-(2,2-dibromovinyl)-4-methoxybenzene 
• 25743-65-1 2,3-dibromo-3-(4-acetoxyphenyl)propionic acid ethyl ester 
• 25743-64-0 3-(4-acetoxyphenyl)acrylic acid ethyl ester 
• 7361-92-4 ethyl 3-(4-hydroxyphenyl)prop-2-enoate 
• 7400-08-0 para-coumaric acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1030828-84-2 3-(4-chlorophenyl)-2-propionic acid ethyl ester 
• 136634-54-3 methyl (4-hydroxyphenyl)propynoate 
• 27914-73-4 4-acetoxybenzoyl chloride 
• 119754-16-4 [4-(tetrahydropyran-2-yloxy)phenyl]ethyne 
• 123-11-5 4-methoxy-benzaldehyde 
• 74189-56-3 4-(tetrahydropyran-2-yloxy)benzaldehyde 

Downstream Products

• 207449-90-9 (4-Hydroxy-phenyl)-propynoic acid 2,4-dinitro-phenyl ester 
• 136762-95-3 rubrolide C 
• 136763-04-7 rubrolide E diacetate 
• 136763-03-6 rubrolide C diacetate 
• 187407-32-5 (Z)-3-(4-acetoxyphenyl)-3-iodoprop-2-enoic acid 
• 1312786-88-1 5-(4-((3-phenoxyphenyl)methoxy)phenyl)isothiazol-3-ol 
• 1312786-89-2 5-(4-((3-phenoxyphenyl)methoxy)phenyl)isothiazol-3-ol 1-oxide 
• 1312788-37-6 3-(4-hydroxyphenyl)propiolic acid amide 
• 1312788-38-7 3-(4-((3-phenoxyphenyl)methoxy)phenyl)propiolic acid amide 
• 1173709-65-3 C₃₃H₅₄O₃ 
• 1173709-64-2 C₃₁H₅₀O₃ 
• 1173709-61-9 C₂₇H₄₂O₃ 
• 136610-14-5 [4-((S)-2-Hydroxy-3-{2-[(morpholine-4-carbonyl)-amino]-ethylamino}-propoxy)-phenyl]-propynoic acid methyl ester 
• 136610-12-3 [4-(2-Hydroxy-3-{2-[(morpholine-4-carbonyl)-amino]-ethylamino}-propoxy)-phenyl]-propynoic acid methyl ester 

Relevant academic research and scientific papers

Preparation method of neoflavonoids

The invention relates to the field of chemical synthesis, in particular to a preparation method of neoflavonoids. The preparation method is characterized by comprising the following steps of using substituted benzaldehyde as an initial raw material to be reacted with malonic acid to generate a substituted phenylacrylic acid compound; performing an addition reaction, an elimination reaction and the like on the substituted phenylacrylic acid compound, or performing acetylation so as to protect a phenolic hydroxyl group, then performing a bromination reaction and the elimination reaction so as to synthesize the substituted phenylpropiolic acid compound ; and using montmorillonite K-10 after being acidulated by sulfuric acid as a catalyst, enabling the substituted phenylpropiolic acid compound and a phenolic compound to perform a heating reaction so as to generate the neoflavonoids. Compared with the prior art, the preparation method of the neoflavonoids, disclosed by the invention, has the characteristics that raw materials are cheap, and easy to obtain, the operation is simple, the catalyst can be recovered for use, and the method is environmentally-friendly, the post-treatment is simple, and the production cost is low, and the method has a high popularization and application value.

NOVEL 3-HYDROXY-5-ARYLISOTHIAZOLE DERIVATIVE

[Problem] To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretagogue and a prophylactic and/or therapeutic agent against diabetes, obesity, or other diseases. [Means of solving the problem] A compound of Formula (I): (where n is 0 to 2; p is 0 to 4; j is 0 to 3; k is 0 to 2; a ring A is an aryl group which is optionally substituted with L or a heterocyclic group which is optionally substituted with L; a ring B is a benzene ring, a pyridine ring, or a pyrimidine ring; X is O, S, —NR7—; and R1 to R7 are specific groups), a salt of the compound, or a solvate of the salt or the compound.

ARYL SULFAMATE DERIVATIVES

The present invention provides an aryl sulfamate derivative represented by Formula (I) (wherein Rr and Rs, which may be the same or different, each represent a hydrogen atom or lower alkyl, R1, R2, R3

An efficient synthesis of neoflavonoid antioxidants based on Montmorillonite K-10 catalysis

A new approach to synthesis of neoflavonoids, based on a high yielding Montmorillonite K-10 catalyzed lactone ring forming cyclization process, is described. The utility of this methodology is exemplified by its employment in the preparation of the substituted 4-phenylneoflavonoids 1-8. The free radical scavenging properties of these substances were evaluated. The neoflavonoids 1 and 5, which mimic esculetin-type antioxidants, were observed to quench hydrazyl free radicals.

Kinetics and Mechanism of the Alkaline Hydrolysis of 2,4-Dinitrophenyl 4′-Hydroxyphenylpropiolate

The alkaline hydrolysis of the title ester was studied in 40 % dioxane/water (v/v) solutions. Kinetic data, reactivity comparisons with model substrates and activation parameters appear to suggest the occurrence of a dissociative E1cB pathway although participation of the associative mechanism cannot be definitely ruled out.

Highly efficient and selective procedures for the synthesis of γ-alkylidenebutenolides via palladium-catalyzed ene-yne coupling and palladium- or silver-catalyzed lactonization of (Z)-2-en-4-ynoic acids. Synthesis of rubrolides A, C, D, and E

The diacetates of rubrolides A, C, D, and E (1 a-d) were prepared in modest yields by the Pd-catalyzed cross coupling-lactonization tandem reaction of 5a or 5b with 6a or 6b using Cl2Pd(PPh3)2 and CuI as catalysts. The feasibility of converting the diacetates into rubrolides was demonstrated by the synthesis of rubrolide C by treatment of 1b with methanolic K2CO3 in THF. A detailed investigation of various parameters and conditions has indicated that formation of the corresponding six-membered lactones 7 and/or the cross coupling-lactonization-Heck substitution products 11 can be serious side reactions under non-optimized conditions and that the use of Pd(PPh3)4 rather than phosphine-free complexes, e.g., CI2Pd(PhCN)2, or complexes of low phosphine content, e.g., Cl2Pd(PPh3)2, along with CuI and NEt3 in MeCN provides satisfactory conditions for the cross coupling-lactonization tandem reaction. Thus, the diacetate of rubrolide A (1a) was prepared in 70% isolated yield. The optimized conditions reported herein appear to be generally applicable to the stereoselective and regioselective synthesis of γ-alkylidenebutenolides in a highly efficient manner.

Development of a highly cardioselective ultra short-acting β-blocker, ONO-1101

A novel, highly cardioselective ultra short-acting β-blocker, ONO-1101, has been developed for application in the emergency treatment of tachycardia and better control of heart rate in surgery. This agent is approximately nine times more potent in β-blocking activity in vivo and eight times more cardioselective in vitro than esmolol. This β-blocking drug has a short duration of activity, enabling rapid recovery after cessation of administration if side effects occur. It can be used safely in patients suffering from acute heart disease and represents a major therapeutic advance in the treatment of heart disease.

NOUVEAU MODE DE CYCLYSATION DE CETO-YLURES. APPLICATION A UNE SYNTHESE IGINALE D'ACYL-3 HYDROXY-4-COUMARINES ET DE L'HYDROXY-11 BENZO-(b) 12 XANTHONE-12

The thermal decomposition of keto-ylides resulting from the reaction of m- and p-acetoxy benzoyl chlorides with Ph3P=CH-COOMe leads, after saponification to m- and p-phenylpropiolic acid respectively.Ortho substitution by an acyl group generally changes the orientation of the reaction.Thus o-acetoxy-, benzoyloxy- or phenylacetoxy benzoyl chlorides respectively afford: and (R=Me,Ph) in satisfactory yields.Saponification of the first and second ones gives: (R=Me, Ph).This constitutes a new, convenient route to 3-acyl 4-hydroxy cumarins and 11-hydroxy 12H-benzoxanthene 12-one.Formation of these last products involves the carbonyl of the acyloxy-substituent and not of the acyl chloride as previously observed in these series.