144261-17-6Relevant articles and documents
H2 cleavage, hydride formation, and catalytic hydrogenation of imines with zinc complexes of C5Me5 and N-heterocyclic carbenes
Jochmann, Phillip,Stephan, Douglas W.
, p. 9831 - 9835 (2013)
Decamethylzincocene, [ZnCp2], reacts with H2 to give the reduced ZnI compound [Zn2Cp2]. In the presence of coordinating and (more efficiently) of non-coordinating N-heterocyclic carbenes (NHCs), the catalytic hydrogenation of imines with H2 is achieved. The monomeric hydride [Zn(Cp)(H)(SIMes)] is presented and its mechanistic implications are considered. Copyright
Structure-Activity Relationship and Biological Investigation of SR18292 (16), a Suppressor of Glucagon-Induced Glucose Production
Cameron, Michael D.,Griffin, Patrick R.,Kamenecka, Theodore M.,Lin, Hua,Lin, Li,Novick, Scott J.,Puigserver, Pere,Ruiz, Claudia,Sharabi, Kfir,Zhu, Di
supporting information, p. 980 - 990 (2021/02/01)
Despite a myriad of available pharmacotherapies for the treatment of type 2 diabetes (T2D), challenges still exist in achieving glycemic control. Several novel glucose-lowering strategies are currently under clinical investigation, highlighting the need f
2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS
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Page/Page column 69, (2010/10/20)
Substituted heteroaryl nitrile derivatives of Formula (I) processes for their preparation, pharmaceutical compositions comprising such compounds and use of the compounds as cysteine protease inhibitors are provided.
