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144494-72-4

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    Cas No: 144494-72-4

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144494-72-4 Usage

General Description

(S)-3-Amino-3-phenyl propionic acid methylester HCl is a chemical compound consisting of an amino acid derivative. It is a methyl ester form of (S)-3-amino-3-phenyl propionic acid, which is a chiral compound with a phenyl group attached to the alpha carbon of the amino acid. The addition of hydrochloric acid to the compound results in the formation of a salt, which can affect its solubility and stability. This chemical may have potential uses in pharmaceuticals, organic synthesis, or as a building block for more complex molecules due to its unique structural properties.

Check Digit Verification of cas no

The CAS Registry Mumber 144494-72-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,4,9 and 4 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 144494-72:
(8*1)+(7*4)+(6*4)+(5*4)+(4*9)+(3*4)+(2*7)+(1*2)=144
144 % 10 = 4
So 144494-72-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO2.ClH/c1-13-10(12)7-9(11)8-5-3-2-4-6-8;/h2-6,9H,7,11H2,1H3;1H/t9-;/m0./s1

144494-72-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl (3S)-3-amino-3-phenylpropanoate,hydrochloride

1.2 Other means of identification

Product number -
Other names methyl 3-amino-3-phenylpropionate hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:144494-72-4 SDS

144494-72-4Relevant articles and documents

Transition Metal-Free N-Arylation of Amino Acid Esters with Diaryliodonium Salts

Kervefors, Gabriella,Kersting, Leonard,Olofsson, Berit

supporting information, p. 5790 - 5795 (2021/03/08)

A transition metal-free approach for the N-arylation of amino acid derivatives has been developed. Key to this method is the use of unsymmetric diaryliodonium salts with anisyl ligands, which proved important to obtain high chemoselectivity and yields. The scope includes the transfer of both electron deficient, electron rich and sterically hindered aryl groups with a variety of different functional groups. Furthermore, a cyclic diaryliodonium salt was successfully employed in the arylation. The N-arylated products were obtained with retained enantiomeric excess.

Synthesis, in vitro and in vivo biological evaluation, docking studies, and structure-activity relationship (SAR) discussion of dipeptidyl boronic acid proteasome inhibitors composed of β-amino acids

Zhu, Yongqiang,Zhu, Xinrong,Wu, Gang,Ma, Yuheng,Li, Yuejie,Zhao, Xin,Yuan, Yunxia,Yang, Jie,Yu, Sen,Shao, Feng,Li, Runtao,Ke, Yanrong,Lu, Aijun,Liu, Zhenming,Zhang, Liangren

supporting information; experimental part, p. 1990 - 1999 (2010/08/03)

A series of novel dipeptidyl boronic acid proteasome inhibitors composed of β-amino acids were synthesized, in vitro and in vivo biologically evaluated, and theoretically modeled for the first time. From the screened racemic compounds in enzyme, 4i was the most active. The IC50 value of its pure enantiomer 4q was 9.6 nM, 36-fold more active than its isomer 4p and as active as the marketed bortezomib in inhibiting human 20S proteasome. This candidate also showed good activities with IC50 values nearly less than 5 μM against several human solid and hematologic tumor cell lines. Safety evaluation in vivo with zebrafish and Sprague-Dawley (SD) rats showed that the candidate 4q was less toxic than bortezomib. Pharmacokinetic profiles suggested candidate 4q showed a more plasma exposure and longer half-life than bortezomib. Docking results indicated that 4q nearly interacted with 20S proteasome in a similar way as bortezomib.

β-amino acids to piperidinones by petasis methylenation and acid-induced cyclization

Adriaenssens, Louis V.,Hartley, Richard C.

, p. 10287 - 10290 (2008/04/12)

(Chemical Equation Presented) Ester-imine derivatives of β-amino acids were methylenated with dimethyltitanocene under microwave irradiation and the resulting enol ethers cyclized with Broensted acid or triisopropylaluminium to give 2,6-syn-disubstituted

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