144564-10-3

Basic information

• Product Name: 2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid
• Synonyms: 2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid
• CAS NO: 144564-10-3
• Molecular Weight: 339.776
• Mol File: 144564-10-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid(144564-10-3)
• EPA Substance Registry System: 2S,3R-1-t-butoxycarbonyl-3-(4-chlorophenyl)-5-oxo-pyrrolidine-2-carboxylic acid(144564-10-3)

Safety Data

• Hazardous Substances Data: 144564-10-3(Hazardous Substances Data)

Upstream product

• 144564-09-0 4R,5S-1-t-butoxycarbonyl-4-(4-chlorophenyl)-5-hydroxymethyl-pyrrolidine-2-one 
• 919349-69-2 (S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-2-oxo-3-phenylselanyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 138629-30-8 (S)-tert-butyl 2-((tert-butyldiphenylsilyloxy)methyl)-5-oxopyrrolidine-1-carboxylate 
• 138871-58-6 (S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-oxo-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester 
• 144564-15-8 4R,5S-1-t-butoxycarbonyl-5-t-butyldiphenylsiloxymethyl-4-(4-chlorphenyl)pyrrolidine-2-one 

Downstream Products

• 78184-72-2 3R-1-t-butoxycarbonylamino-3-(4-chlorophenyl)butanoic acid 
• 63701-55-3 (R)-(-)-baclofen hydrochloride 
• 402580-39-6 (2S,3R)-2-tert-Butoxycarbonylamino-3-(4-chloro-phenyl)-pentanedioic acid 

Relevant articles and documents

Synthesis of Homochiral 3-Substituted Glutamic Acids and Prolines from Pyroglutamic Acid

Efficient syntheses of (2S,3S)-methylproline (5a) and (2S,3R)-phenylproline (5b) are described, starting from the readily available pyroglutaminol derivatives 2a and 2b via conjugate 1,4=addition of organocuprates to 1.Catalytic hydrogenation of 3 from th