1445985-81-8

Basic information

• Product Name: (R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone
• Synonyms: (R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone
• CAS NO: 1445985-81-8
• Molecular Weight: 519.538
• Mol File: 1445985-81-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone(1445985-81-8)
• EPA Substance Registry System: (R)-(3-(4-(4-aminobutyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone(1445985-81-8)

Safety Data

• Hazardous Substances Data: 1445985-81-8(Hazardous Substances Data)

Upstream product

• 1224640-11-2 1-cyclopropyl-4-hydroxy-1,2,3,4-tetrahydroquinoxaline-2,3-dione 
• 1224640-12-3 1-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-2,3-dione 
• 1224640-13-4 1-cyclopropyl-1,2,3,4-tetrahydro-quinoxaline 
• 1445985-47-6 tert-butyl (4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidine-3-carboxylate 
• 1445985-48-7 1-cyclopropyl-4-[[(4R)-1,3-thiazolidin-4-yl]carbonyl]-1,2,3,4-tetrahydroquinoxaline 
• 1445985-78-3 tert-butyl 4-(2,5-dichloro-4-formylphenyl)butylcarbamate 
• 1445985-79-4 tert-butyl N-[4-[2,5-dichloro-4-(hydroxymethyl)phenyl]butyl]carbamate 
• 1445985-80-7 (R)-tert-butyl 4-(2,5-dicbloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)butylcarbamate 
• 55432-23-0 cyclopropyl-(2-nitro-phenyl)-amine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 1224640-10-1 N-cyclopropyl-N-(2-nitro-phenyl)-oxalamic acid methyl ester 
• 1984-58-3 2,5-dichloroanisole 
• 381229-74-9 4-methoxy-3,6-dichlorobenzaldehyde 
• 27164-10-9 2,5-dichloro-4-hydroxybenzaldehyde 

Downstream Products

• 1445983-93-6 (R)-1-(4-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)butyl)-3-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)urea 

Relevant articles and documents

Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5)

Bile acid signaling and metabolism in the gastrointestinal tract have wide-ranging influences on systemic disease. G protein-coupled bile acid receptor 1 (GPBAR1, TGR5) is one of the major effectors in bile acid sensing, with demonstrated influence on metabolic, inflammatory, and proliferative processes. The pharmacologic utility of TGR5 agonists has been limited by systemic target-related effects such as excessive gallbladder filling and blockade of gallbladder emptying. Gut-restricted TGR5 agonists, however, have the potential to avoid these side effects and consequently be developed into drugs with acceptable safety profiles. We describe the discovery and optimization of a series of gut-restricted TGR5 agonists that elicit a potent response in mice, with minimal gallbladder-related effects. The series includes 12 (TGR5 EC50: human, 143 nM; mouse, 1.2 nM), a compound with minimal systemic availability that may have therapeutic value to patients with type 2 diabetes mellitus, nonalcoholic steatohepatitis, or inflammatory bowel disease.