1446029-58-8

Basic information

• Product Name: (E)-1-nitro-4-(4,4,4-trifluorobut-1-en-1-yl)benzene
• Synonyms: (E)-1-nitro-4-(4,4,4-trifluorobut-1-en-1-yl)benzene
• CAS NO: 1446029-58-8
• Molecular Weight: 231.174
• Mol File: 1446029-58-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (E)-1-nitro-4-(4,4,4-trifluorobut-1-en-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-nitro-4-(4,4,4-trifluorobut-1-en-1-yl)benzene(1446029-58-8)
• EPA Substance Registry System: (E)-1-nitro-4-(4,4,4-trifluorobut-1-en-1-yl)benzene(1446029-58-8)

Safety Data

• Hazardous Substances Data: 1446029-58-8(Hazardous Substances Data)

Upstream product

• 35271-56-8 (E)-4-nitrocinnamyl alcohol 
• 1461634-28-5 (2,2-difluorocyclopropyl)(4-nitrophenyl)methanone 
• 325810-07-9 tris(triphenylphosphane)(trifluoromethyl)copper(I) 
• 21122-96-3 α-(4-Nitro-phenyl)-allylchlorid 
• 71269-07-3 3-(4-nitrophenyl)-2-propenyl chloride 

Relevant articles and documents

Dehydrative Ring-Opening of gem-Difluorocyclopropyl Carbinols to Allylic Trifluoromethyl and Difluorohalomethyl Derivatives Promated by Titanium Tetrahalide

We report herein the titanium tetrahalide-promoted dehydrative ring-opening of gem-difluorocyclopropyl carbinols as a novel method for the synthesis of (E)-allylic CF3, (E)-allylic CF2Cl, and (E)-allylic CF2Br compounds. This TiF4-promoted reaction appears to proceed via a concerted SN2' mechanism. A control experiment revealed that the TiCl4-promoted ring-opening initially proceeds by conversion of the gem-difluorocyclopropyl carbinol into a gem-difluorocyclopropyl chloride intermediate.

Copper-catalyzed decarboxylative trifluoromethylation of allylic bromodifluoroacetates

The development of new synthetic fluorination reactions has important implications in medicinal, agricultural, and materials chemistries. Given the prevalence and accessibility of alcohols, methods to convert alcohols to trifluoromethanes are desirable. However, this transformation typically requires four-step processes, specialty chemicals, and/or stoichiometric metals to access the trifluoromethyl-containing product. A two-step copper-catalyzed decarboxylative protocol for converting allylic alcohols to trifluoromethanes is reported. Preliminary mechanistic studies distinguish this reaction from previously reported Cu-mediated reactions.