1446250-90-3

Basic information

• Product Name: C₂₈H₃₈N₆O₄S
• CAS NO: 1446250-90-3
• Molecular Weight: 554.714
• Mol File: 1446250-90-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₃₈N₆O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₃₈N₆O₄S(1446250-90-3)
• EPA Substance Registry System: C₂₈H₃₈N₆O₄S(1446250-90-3)

Safety Data

• Hazardous Substances Data: 1446250-90-3(Hazardous Substances Data)

Upstream product

• 72470-43-0 2-phenylbenzimidazole-4-carboxylic acid methyl ester 
• 65-85-0 benzoic acid 
• 1339114-58-7 rac-1-methylsulfonyl-4-(oxiranylmethyl)piperazine 
• 55276-43-2 4-methanesulfonylpiperazine 
• 107582-20-7 2,3-diaminobenzoic acid methyl ester 
• 1446250-98-1 C₁₄H₃₀N₄O₃S 
• 66630-72-6 2-Phenyl-4-benzimidazolylcarboxylic acid 

Relevant articles and documents

Discovery of TD-8954, a clinical stage 5-HT4 receptor agonist with gastrointestinal prokinetic properties

The discovery of a series of 5-HT4 receptor agonists based on a novel 2-alkylbenzimidazole aromatic core is described. Optimization of the 2-substituent of the benzimidazole ring led to a series of agonists with subnanomolar binding affinity and moderate-to-high intrinsic activity relative to that of 5-HT. Consistent with our previously described multivalent design approach to this target, subsequent optimization of the linker and secondary binding group regions of the series afforded compound 18 (TD-8954), a potent and selective 5-HT4 receptor agonist in vitro with demonstrated prokinetic activity in multiple species.