72470-43-0

Basic information

• Product Name: 1H-Benzimidazole-4-carboxylic acid, 2-phenyl-, methyl ester
• CAS NO: 72470-43-0
• Molecular Formula: C15H12N2O2
• Molecular Weight: 252.272
• Mol File: 72470-43-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole-4-carboxylic acid, 2-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-4-carboxylic acid, 2-phenyl-, methyl ester(72470-43-0)
• EPA Substance Registry System: 1H-Benzimidazole-4-carboxylic acid, 2-phenyl-, methyl ester(72470-43-0)

Safety Data

• Hazardous Substances Data: 72470-43-0(Hazardous Substances Data)

Upstream product

• 57113-91-4 methyl 3-nitroanthranilate 
• 95067-27-9 2-acetylamino-3-nitro-benzoic acid methyl ester 
• 107582-20-7 2,3-diaminobenzoic acid methyl ester 
• 65-85-0 benzoic acid 
• 100-52-7 benzaldehyde 
• 98-88-4 benzoyl chloride 
• 100-46-9 benzylamine 
• 5337-09-7 2-bromo-3-nitro-benzoic acid methyl ester 
• 181135-43-3 methyl 2-amino-3-N-benzoylaminobenzoate 

Downstream Products

• 66630-72-6 2-Phenyl-4-benzimidazolylcarboxylic acid 
• 1446250-90-3 C₂₈H₃₈N₆O₄S 
• 579525-39-6 1-[2-(trimethylsilyl)ethoxymethyl]-2-phenylbenzimidazole-4-methanol 
• 579525-37-4 1-[2-(trimethylsilyl)ethoxymethyl]-2-phenylbenzimidazole-4-carboxylic acid methyl ester 
• 579525-38-5 1-[2-(trimethylsilyl)ethoxymethyl]-2-phenylbenzimidazole-7-carboxylic acid methyl ester 
• 72470-44-1 NU₁₀₇₀ 

Relevant articles and documents

An efficient synthesis, characterization and biological activity of novel Schiff bases of 2-aryl-1H-benzo[d]imidazole-4-carbohydrazide derivatives

A series of N′-aryllidene-2-aryl-1H-benzo[d]imidazole-4-carbohydrazide (Schiff bases) 3a1-3d4 were synthesized by condensation reaction of 2-aryl-1H-benzo[d]imidazole-4-carbohydrazide (2a-2d) with substituted aromatic aldehyde. The c

Discovery of TD-8954, a clinical stage 5-HT4 receptor agonist with gastrointestinal prokinetic properties

The discovery of a series of 5-HT4 receptor agonists based on a novel 2-alkylbenzimidazole aromatic core is described. Optimization of the 2-substituent of the benzimidazole ring led to a series of agonists with subnanomolar binding affinity and moderate-to-high intrinsic activity relative to that of 5-HT. Consistent with our previously described multivalent design approach to this target, subsequent optimization of the linker and secondary binding group regions of the series afforded compound 18 (TD-8954), a potent and selective 5-HT4 receptor agonist in vitro with demonstrated prokinetic activity in multiple species.

AROMATIC AMINO ACID DERIVATIVES AND MEDICINAL COMPOSITIONS

An aromatic amino acid derivative represented by the formula ( I ) or its pharmacologically acceptable salt: wherein,R1 is a hydrogen atom or an amino-protecting group,R2 is a halogen atom or an alkyl, aralkyl or aryl group,R3 is 1○ a hydrogen atom, 2○ an aroylamino group, 3○ a phenyl group substituted with lower alkyl, phenyl, phenoxy, etc. 4○ a naphthyl or tetrahydronaphthyl group optionally substituted with hydroxy, lower alkoxy or di(lower)alkylamino, 5○ an unsaturated mono-cyclic heterocyclic group containing N, O and/or S substituted with lower alkyl, phenyl, naphthyl or tetrahydroquinolyl, 6○ an unsaturated or partially saturated condensed heterocyclic group containing N, O and/or S, optionally substituted with oxo, carboxy, amino, lower alkyl, etc.; X is a halogen atom, an alkyl group or an alkoxy group; Y is oxygen atom or nitrogen atom; 1 is 0 or 1; m is 0, 1 or 2; n is an integer of 0-5. This compound can inhibit a transporter (LAT1) of essential amino acid which is one of main nutrition for cancer cells and accordingly cause drain of the essential amino acid on the cancer cells and finally can prohibit the multiplication of cancer cells.