14469-77-3

Upstream product

• 920-98-9 N,N-dimethylacetamide-dimethyl sulfate complex 
• 18871-66-4 N,N-dimethylacetamide dimethyl acetal 
• 542-92-7 cyclopenta-1,3-diene 
• 127-19-5 N,N-dimethyl acetamide 
• 703-24-2 6,6-bis(dimethylamino)pentafulvene 
• 77-78-1 dimethyl sulfate 
• 19429-85-7 N,N-dimethylacetamide diethyl acetal 

Downstream Products

• 999-59-7 methyl (2E)-3-(dimethylamino)prop-2-enoate 
• 1271-55-2 acetylferrocene 
• 1374355-33-5 C₂₁H₁₄BF₁₀N 
• 1374355-32-4 C₄₁H₃₉BF₁₀NP 

Relevant academic research and scientific papers

1,1-Bis(1″,2″,3″,4″,5″-pentamethylferrocen- 1′-yl)ethene

1,1-Bis(1″,2″,3″,4″,5″-pentamethylferrocen- 1′-yl)ethene (6) was synthezised as a prototype of two metallocenes that are bridged by the sp2-carbon center of a vinylidene group. Starting from 6-N,N-dimethylamino-6-methylfulvene, the iron-containing intermediates were a pentamethylferrocenyl-substituted fulvene and an ethene that was geminally disubstituted by a Cp anion and a pentamethylferrocenyl moiety. Besides other methods, the ferrocenes were characterized by NMR spectroscopy including full signal assignment. The bimetallic compound 6 showed moderate interactions between the two ferrocenes in the cyclic voltammogram (ΔE1/2=150 mV). According to X-ray crystal structure analysis compound 6 is a twisted molecule; the vinylidene moiety and the Cps of the neighboring ferrocenes are not coplanar.

Synthesis of benzobicyclo[2.2.1] heptylimidazoles as conformationally constrained adrenergic receptor antagonists

A facile method for the preparation of conformationally rigid analogues of the adrenergic α-2 receptor antagonist atipamezole and the adrenergic α-2 receptor agonist medetomidine has been developed. The efficient benzyne [4+2] cycloaddition reaction was used to give the core 7-acetylbenzonorbornadiene structure, which was subsequently elaborated to the corresponding imidazole-based syn and anti isomers by means of the classical Bredereck's method.

PTP-1B inhibitors: Cyclopenta[d][1,2]-oxazine derivatives

A series of novel cyclopenta[d][1,2]-oxazine derivatives was prepared and evaluated for their inhibitory activity toward protein tyrosine phosphatase 1B (PTP-1B). Compound 6s was found to be an inhibitor of PTP-1B with nanomolar IC50 value and

Organic transformations at a group 4 metallocene framework: Formation of a rigid ansa-metallocene by Mannich-type carbon-carbon coupling

New metallocene Ziegler catalysts are generated by activation of the rigid ansa-metallocenes 2 with methylalumoxane. Complexes 2 are formed by application of an acid-catalyzed Mannich reaction - a classical reaction from the synthetic organic repertoire - of complexes 1, which are readily available by means of a fulvene route.

Formation of a Constrained-Geometry Ziegler Catalyst System Containing a C1 Instead of the Usual Si1 Connection between the Cyclopentadienyl and Amido Ligand Components

6-Amino-6-methylfulvene (4) is cleanly N-acylated by treatment with pivaloylchloride/triethylamine to give the fulvene (C5H4)=C(CH3)NHCOCMe3 (5c). Treatment of 4 with trimethylchlorosilane similarly yields the m

6-Dimethylamino-6-lithiofulvene, a novel 6-fulvenyl anion of potential synthetic utility

Treatment of 6,6-bis(dimethylamino)fulvene with 2.2 equiv. of lithium naphthalenide in THF generates, via two-electron reduction and deamination, 6-dimethylamino-6-lithiofulvene which is a new 6-fulvenyl anion of potential utility for the synthesis of a variety of 6-aminofulvenes and related compounds.