144690-07-3

Basic information

• Product Name: OlMesartan interMediate iMpurity II
• Synonyms: OlMesartan interMediate iMpurity II;1H-IMidazole-4-carboxylic acid, 5-acetyl-2-propyl-, ethyl ester;Olmesartan intermediate impurity Ⅰ;4-ACETYL-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;5-Acetyl-2-propyl-1H-Imidazole-4-carboxylic Acid Ethyl Ester;Ethyl 4-acetyl-2-propyl-1H-imidazole-5-carboxylate;Olmesartan Medoxomil Impurity 6
• CAS NO: 144690-07-3
• Molecular Formula: C₁₁H₁₆N₂O₃
• Molecular Weight: 224.25634
• Mol File: 144690-07-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 438.5±30.0 °C(Predicted)
• Appearance: /
• Density: 1.142±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 9.05±0.10(Predicted)
• CAS DataBase Reference: OlMesartan interMediate iMpurity II(CAS DataBase Reference)
• NIST Chemistry Reference: OlMesartan interMediate iMpurity II(144690-07-3)
• EPA Substance Registry System: OlMesartan interMediate iMpurity II(144690-07-3)

Safety Data

• Hazardous Substances Data: 144690-07-3(Hazardous Substances Data)

Usage

Uses

5-Acetyl-2-propyl-1H-Imidazole-4-carboxylic Acid Ethyl Ester is used in the synthetic preparation of imidazole-5-carboxylic acids bearing alkyl, alkenyl, and hydroxyalkyl substituents at the 4-position and their related compounds.

Upstream product

• 51802-42-7 2-propylimidazole-4,5-dicarbonitrile 
• 144690-06-2 4-acetyl-2-propylimidazole-5-carbonitrile 
• 64-17-5 ethanol 
• 1025972-83-1 4-acetyl-2-propylimidazole-5-carboxylic acid 

Downstream Products

• 172875-53-5 ethyl 4-(1-hydroxy-1-methylpropyl)-2-propylimidazole-5-carboxylate 
• 172875-72-8 5-(1-Hydroxy-ethyl)-2-propyl-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid ethyl ester 
• 1026598-44-6 Oxalic acid 1-[1-(2'-tert-butoxycarbonyl-biphenyl-4-ylmethyl)-5-ethoxycarbonyl-2-propyl-1H-imidazol-4-yl]-ethyl ester ethyl ester 
• 172875-55-7 3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-propyl)-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 144689-43-0 ethyl 4-(1-hydroxyethyl)-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate 
• 172875-66-0 3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-(1-hydroxy-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 172876-07-2 3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-ethyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 172875-77-3 3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-propyl)-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 
• 172876-11-8 3-(2'-Carboxy-biphenyl-4-ylmethyl)-5-ethyl-2-propyl-3H-imidazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

ANGIOTENSIN II ANTAGONIST 1-BIPHENYLMETHYLIMIDAZOLE COMPOUNDS AND THEIR THERAPEUTIC USE

Compounds of the following formula (I) or the formula (I) p : STR1 wherein R 1 is alkyl or alkenyl; R 2 and R 3 are hydrogen, alkyl, alkenyl, cycloalkyl, aralkyl, aryl, or aryl fused to cycloalkyl; R 4 is hydrogen, alkyl, alkanoyl, alkenoyl, arylcarbonyl, alkoxycarbonyl, tetrahydropyranyl, tetrahydrothiopyranyl, tetrahydrothienyl, tetrahydrofuryl, a group of formula--SiR a R b R c, in which R a, R b and R c are alkyl or aryl, alkoxymethyl, (alkoxyalkoxy)methyl, haloalkoxymethyl, aralkyl, aryl or alkanoyloxymethoxycarbonyl; R 5 is carboxy or--CONR 8 R 9, wherein R 8 and R 9 hydrogens or alkyl, or R 8 and R 9 together form alkylene; R 6 is hydrogen, alkyl, alkoxy or halogen; R. sup.7 is carboxy or tetrazol-5-yl; R p. sup.1 is hydrogen, alkyl, cycloalkyl or alkanoyl; R p 2 is a single bond, alkylene or alkylidene; R p 3 and R p 4 are each hydrogen or alkyl; R. sub.p 6 is carboxy or tetrazol-5-yl; and X p is oxygen or sulfur; and pharmaceutically acceptable salts and esters thereof. The compounds are AII receptor antagonists and thus have hypotensive activity and can be used for the treatment and prophylaxis of hypertension. The compounds may be prepared by reacting a biphenylmethyl compound with an imidazole compound.