1447-14-9

Basic information

• Product Name: 2,2-DICHLORO-1-METHYLCYCLOPROPANECARBOXYLIC ACID
• Synonyms: 2,2-DICHLORO-1-METHYLCYCLOPROPANECARBOXYLIC ACID;LABOTEST-BB LT00452792;1-Methyl-2,2-dichlorocyclopropane-1-carboxylic acid;1-Methyl-2,2-dichlorocyclopropanecarboxylic acid;2,2-Dichloro-1-methyl-cyclopropanecarboxylic acid 98%;2,2-dichloro-1-methyl-1-cyclopropanecarboxylic acid
• CAS NO: 1447-14-9
• Molecular Formula: C₅H₆Cl₂O₂
• Molecular Weight: 169.01
• EINECS: 215-901-6
• Product Categories: C1 to C5;Carbonyl Compounds;Carboxylic Acids;Building Blocks;C1 to C5;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
• Mol File: 1447-14-9.mol

Chemical Properties

• Melting Point: 60-65 °C(lit.)
• Boiling Point: 85 °C8 mm Hg(lit.)
• Flash Point: 87.7°C
• Appearance: /
• Density: 1.3010 (estimate)
• Vapor Pressure: 0.135mmHg at 25°C
• Refractive Index: 1.53
• PKA: 3.51±0.50(Predicted)
• BRN: 1937304
• CAS DataBase Reference: 2,2-DICHLORO-1-METHYLCYCLOPROPANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-DICHLORO-1-METHYLCYCLOPROPANECARBOXYLIC ACID(1447-14-9)
• EPA Substance Registry System: 2,2-DICHLORO-1-METHYLCYCLOPROPANECARBOXYLIC ACID(1447-14-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 1760
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 1447-14-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,2-DICHLORO-1-METHYLCYCLOPROPANECARBOXYLIC ACID is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique structure allows it to be a key component in the synthesis of complex molecules with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2,2-DICHLORO-1-METHYLCYCLOPROPANECARBOXYLIC ACID serves as a versatile building block for creating a wide range of chemical products. Its reactivity and structural features make it a valuable asset in the synthesis of various organic compounds.
Used in Solid Phase Synthesis:
2,2-DICHLORO-1-METHYLCYCLOPROPANECARBOXYLIC ACID is used as a key component in the solid phase synthesis of α-hydroxy esters. These esters are important due to their potential applications in various industries, including pharmaceuticals and materials science.
Used in Inhibitors of Amyloid-β Production:
In the field of neurodegenerative disease research, 2,2-DICHLORO-1-METHYLCYCLOPROPANECARBOXYLIC ACID has been utilized in the development of inhibitors for amyloid-β production. Amyloid-β is a protein fragment that has been implicated in the development of Alzheimer's disease, and inhibiting its production could potentially slow the progression of the disease.

InChI:InChI=1/C5H6Cl2O2/c1-4(3(8)9)2-5(4,6)7/h2H2,1H3,(H,8,9)

Upstream product

• 5296-49-1 1-vinyl-1-methyl-2,2-dichlorocyclopropane 
• 563-41-7 semicarbazide hydrochloride 
• 79-41-4 poly(methacrylic acid) 
• 67-66-3 chloroform 
• 56-37-1 N-benzyl-N,N,N-triethylammonium chloride 
• 292638-85-8 acrylic acid methyl ester 
• 35757-05-2 2,2-dichloro-1-methylcyclopropanecarbonitrile 
• 91772-23-5 2,2-Dichlor-1-methyl-1--cyclopropan 
• 35749-17-8 2,2-dichloro-1-methylcyclopropylcarboxamide 

Downstream Products

• 1447-13-8 methyl 2,2-dichloro-1-methylcyclopropanecarboxylate 
• 56447-09-7 2,2-dichloro-1-methyl-cyclopropanoyl chloride 
• 81513-06-6 trans-2-chloro-1-methylcyclopropanecarboxylic acid 
• 701223-12-3 (1S)-2,2-dichloro-1-methylcyclopropanecarbonyl chloride 
• 701223-27-0 (-)-(1S)-2,2-dichloro-1-methylcyclopropyl(phenyl)methanone 
• 701223-31-6 (-)-(1S)-2,2-dichloro-1-methylcyclopropyl(2-chlorophenyl)methanone 
• 701223-23-6 (-)-(1S)-2,2-dichloro-1-methylcyclopropyl(o-tolyl)methanone 
• 701223-35-0 (-)-(1S)-2,2-dichloro-1-methylcyclopropyl(2-methoxyphenyl)methanone 
• 701222-62-0 (-)-(S)-[(1S)-2,2-dichloro-1-methylcyclopropyl](phenyl)(o-tolyl)methanol 
• 701222-66-4 (-)-(R)-[(1S)-2,2-dichloro-1-methylcyclopropyl](phenyl)(o-tolyl)methanol 
• 701222-72-2 (-)-(S)-[(1S)-2,2-dichloro-1-methylcyclopropyl](2-chlorophenyl)(phenyl)methanol 
• 701222-77-7 (-)-[(1S)-2,2-dichloro-1-methylcyclopropyl]bis(2-chlorophenyl)methanol 
• 701222-89-1 (-)-(R)-[(1S)-2,2-dichloro-1-methylcyclopropyl](2-chlorophenyl)(2-methoxyphenyl)methanol 
• 701222-83-5 (-)-(S)-[(1S)-2,2-dichloro-1-methylcyclopropyl](2-methoxyphenyl)(o-tolyl)methanol 

Relevant articles and documents

Low-Temperature Ozonolysis of 2-Alkenyl-1,1-dichlorocyclopropanes

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