144757-83-5Relevant academic research and scientific papers
Synthesis of Polysubstituted Quinolines from α-2-Aminoaryl Alcohols Via Nickel-Catalyzed Dehydrogenative Coupling
Das, Sanju,Maiti, Debabrata,De Sarkar, Suman
, p. 2309 - 2316 (2018)
This study reports a nickel-catalyzed sustainable synthesis of polysubstituted quinolines from α-2-aminoaryl alcohols by a sequential dehydrogenation and condensation process that offers the advantages of a low catalyst loading and wide substrate scope. In contrast to earlier reported methods, this strategy allows the use of both primary as well as secondary α-2-aminoaryl alcohols in combination with either ketones or secondary alcohols for desired product formation. Using this methodology, 30 substituted quinoline derivatives were synthesized with up to 93% isolated yields.
A Tf2O-Promoted Synthesis of Functionalized Quinolines from Ketoximes and Alkynes
Zheng, Weiping,Yang, Weiguang,Luo, Dongping,Min, Lin,Wang, Xinyan,Hu, Yuefei
supporting information, p. 1995 - 1999 (2019/03/13)
A new general synthesis of quinolines was developed from ketoximes and alkynes in the presence of Tf2O. It offered the first direct synthesis of quinolines by using the nitrilium salts generated in situ from a Tf2O-promoted Beckmann rearrangement of ketoximes under very easy conditions. (Figure presented.).
Synthesis of multi-functionalized quinolines and 1,2-dihydroquinolines through FeCl3-mediated reactions of carbonyl compounds with 2-vinylanilines
Liu, Sha,Li, Gaoqiang,Xu, Feng
, p. 888 - 892 (2018/07/25)
A facile and efficient approach toward the synthesis of functionalized quinolines and 1,2-dihydroquinolines from carbonyl compounds and 2-vinylanilines is described. The protocol utilizes the nonhazardous and less expensive FeCl3 as catalyst wi
An efficient synthesis of substituted quinolines via indium(III) chloride catalyzed reaction of imines with alkynes
Zhu, Mei,Fu, Weijun,Xun, Chen,Zou, Guanglong
experimental part, p. 43 - 47 (2012/03/10)
An efficient synthetic method for the preparation of quinolines through indium(III) chloride-catalyzed tandem addition-cyclization-oxidation reactions of imines with alkynes was developed. The processes can provide a diverse range of quinoline derivatives
Copper(I)- And gold(I)-catalyzed synthesis of 2,4-disubstituted quinoline derivatives from N-Aryl-2-propynylamines
Kuninobu, Yoichiro,Inoue, Yuichi,Takai, Kazuhiko
, p. 1422 - 1423 (2008/03/14)
2,4-Disubstituted quinoline derivatives were obtained from N-aryl-2-propynylamines catalyzed by copper(I) and gold(I) complexes. The quinoline derivatives could also be obtained by the reaction of N-arylaldimines with terminal acetylenes via the formation of N-aryl-2-propynylamines. Copyright
Nickel-catalyzed cyclization of 2-iodoanilines with aroylalkynes: An efficient route for quinoline derivatives
Korivi, Rajendra Prasad,Cheng, Chien-Hong
, p. 7079 - 7082 (2007/10/03)
An efficient and convenient nickel-catalyzed cyclization of 2-iodoanilines with alkynyl aryl ketones to give 2,4-disubstituted quinolines was developed. The reaction can be employed for the synthesis of naturally occurring quinoline derivatives in good yields. On the basis of the regiochemistry of the products, the possible pathway for the reaction is via the formation of o-aminochalcone.
On the reaction of N-arylnitrilium salts with acetylenes: Synthesis of substituted quinolines
Al-Talib,Jochims,Wang,Hamed,Ismail
, p. 875 - 878 (2007/10/02)
Quinolinium salts 3 are obtained from the reaction of N-arylnitrilium salts 1 with acetylenes 2. With aqueous base the salts 3 are transformed into the corresponding quinolines 4.
