1448441-15-3

Basic information

• Product Name: (S)-N-(2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)phenyl)-1-pivaloylpyrrolidine-2-carboxamide
• Synonyms: (S)-N-(2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)phenyl)-1-pivaloylpyrrolidine-2-carboxamide
• CAS NO: 1448441-15-3
• Molecular Weight: 419.48
• Mol File: 1448441-15-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-N-(2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)phenyl)-1-pivaloylpyrrolidine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-(2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)phenyl)-1-pivaloylpyrrolidine-2-carboxamide(1448441-15-3)
• EPA Substance Registry System: (S)-N-(2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)phenyl)-1-pivaloylpyrrolidine-2-carboxamide(1448441-15-3)

Safety Data

• Hazardous Substances Data: 1448441-15-3(Hazardous Substances Data)

Upstream product

• 1448441-13-1 (S)-methyl 2-(2-(1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoate 
• 1129527-34-9 2-{2-[(pyrrolidine-2-carbonyl)-amino]benzoylamino}benzoic acid methyl ester 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 49854-16-2 methyl 2-(2-aminobenzoylamino)benzoate 
• 72367-10-3 2-(2-nitrobenzoylamino)benzoic acid methyl ester 
• 134-20-3 2-carbomethoxyaniline 
• 610-14-0 2-nitrobenzyl chloride 
• 1448441-14-2 (S)-2-(2-(1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoic acid 

Downstream Products

• 1448441-07-3 2-[2-({1-[2-(2-{[1-(2,2-dimethylpropionyl)pyrrolidine-2-carbonyl]amino}benzoylamino)benzoyl]pyrrolidine-2-carbonyl}amino)benzoylamino]benzoic acid methyl ester 
• 1448441-05-1 2-[2-({1-[2-(2-{[1-(2,2-dimethylpropionyl)pyrrolidine-2-carbonyl]amino}benzoylamino)benzoyl]pyrrolidine-2-carbonyl}amino)benzoylamino]benzoic acid methyl amide 
• 1448441-16-4 methyl 2-(2-((S)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamido) benzamido)benzoate 
• 1448441-09-5 (S)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl)-1-(2-(2-((S)-1-pivaloylpyrrolidine-2-carboxamido)benzamido)benzoyl)pyrrolidine-2-carboxamide 

Relevant articles and documents

A synthetic zipper peptide motif orchestrated via co-operative interplay of hydrogen bonding, aromatic stacking, and backbone chirality

Here, we report on a new class of synthetic zipper peptide which assumes its three-dimensional zipper-like structure via a co-operative interplay of hydrogen bonding, aromatic stacking, and backbone chirality. Structural studies carried out in both solid- and solution-state confirmed the zipper-like structural architecture assumed by the synthetic peptide which makes use of unusually remote inter-residual hydrogen-bonding and aromatic stacking interactions to attain its shape. The effect of chirality modulation and the extent of noncovalent forces in the structure stabilization have also been comprehensively explored via single-crystal X-ray diffraction and solution-state NMR studies. The results highlight the utility of noncovalent forces in engineering complex synthetic molecules with intriguing structural architectures.