144872-54-8 Usage
Uses
Used in Medical Research:
Uridine, 2'-deoxy-5-iodo-, 3'-benzoate is used as a radioiodinated tracer for the study of nucleoside transporters in various tissues and organs. It aids in understanding the mechanisms and pathways involved in nucleoside uptake and metabolism in cells, which is crucial for the development of nucleoside analogue drugs and other therapeutic agents.
Used in Drug Development:
In the pharmaceutical industry, 5-IDU is utilized as a tool to investigate the efficacy and mechanisms of action of nucleoside analogue drugs. Its application helps in the discovery and optimization of new drugs targeting nucleoside transporters, potentially leading to the development of novel therapeutics for various diseases.
Used in Diagnostic Imaging:
In the field of diagnostic imaging, Uridine, 2'-deoxy-5-iodo-, 3'-benzoate serves as a valuable tracer for positron emission tomography (PET) scans. It can be used to visualize the activity of nucleoside transporters in vivo, providing insights into the distribution and function of these transporters in health and disease.
Used in Cellular Biology Studies:
In cellular biology, 5-IDU is employed as a research tool to explore the role of nucleoside transporters in cellular processes such as cell growth, differentiation, and apoptosis. Its use in these studies contributes to a deeper understanding of the fundamental biological processes and their regulation by nucleoside transporters.
Check Digit Verification of cas no
The CAS Registry Mumber 144872-54-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,8,7 and 2 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 144872-54:
(8*1)+(7*4)+(6*4)+(5*8)+(4*7)+(3*2)+(2*5)+(1*4)=148
148 % 10 = 8
So 144872-54-8 is a valid CAS Registry Number.
144872-54-8Relevant academic research and scientific papers
Syntheses of inhibitors for the enzyme thymidine 5'-diphosphate-glucose-4,6-dehydratase (EC 4.2.1.46)
Naundorf, Andreas,Klaffke, Werner
, p. 38 - 51 (2007/10/03)
Inhibitors of the enzyme thymidine 5'-diphosphate-glucose-4,6-dehydratase (EC 4.2.1.46) were synthesised starting from thymidine, 2-deoxy-uridine and -cytidine. The diphosphate moieties have either been replaced by methylene diphosphonate or phosphoryl hy
Synthesis of a D-lactosyl cluster-nucleoside conjugate
Vaino, Andrew R.,Depew, William T.,Szarek, Walter A.
, p. 1871 - 1872 (2007/10/03)
The synthesis of a nucleoside-oligolactoside conjugate, expected to provide site-specific drug delivery to the human liver, is described.
A mild and efficient method for the deprotection of tert-butyldimethylsilyl ethers using iodine in methanol
Vaino, Andrew R.,Szarek, Walter A.
, p. 2351 - 2352 (2007/10/03)
An effective method for the cleavage of tert-butyldimethylsilyl ethers using a 1% solution of iodine in methanol is described.
Synthesis of Analogues of 5-Iodo-2'-deoxyuridine-5'-diphosphate
Jennings, L. John,Macchia, Marco,Parkin, Ann
, p. 2197 - 2202 (2007/10/02)
The synthesis of three types of diphosphate analogues of 5-iodo-2'-deoxyuridine-5'-diphosphate is reported.Routes are described to the 5'-phosphonoacetamido, the 5'-N-phosphonosulfamoyl and the 5'-O-sulfamoylcarbamoyl derivatives, 2, 3 and 4 starting from
