1449701-71-6Relevant articles and documents
Efficient synthesis of indene derivatives by cascade reactions
-
Paragraph 0055; 0056, (2017/01/09)
The present invention relates to an efficient synthesis method of indene derivatives through cascade reaction. In the present invention, a novel one-pot cascade approach to the synthesis of 1H-indene-3-carboxamides and 1H-indene-3-carboxylate derivatives through thermolysis of a diazo compound is developed. Along with various aromatic and heteroaromatic aldehydes, aliphatic or aromatic primary amine and aliphatic alcohol or phenol derivative are used as nucleophilic components. In the present invention, a multicomponent reaction without using a catalyst enables the synthesis of variously functionalized indene derivatives, and can be widely applied to the synthesis of natural products and medicine.
Synthesis of diverse indene derivatives from 1-diazonaphthalen-2(1 H)-ones via thermal cascade reactions
Somai Magar, Krishna Bahadur,Lee, Yong Rok
, p. 4288 - 4291 (2013/09/24)
A sequential Wolff rearrangement of 1-diazonaphthalen-2(1H)-ones followed by trapping of the ketene intermediate with primary and aromatic amines or alcohols and phenols in the presence of various aldehydes generates 1H-indene-3-carboxamides or 1H-indene-3-carboxylates. This constitutes an unprecedented three-component coupling reaction that allows for the synthesis of functionalized indene derivatives under catalyst-free thermal conditions.
