1450654-49-5

Upstream product

• 110238-91-0 tetrahydropyran-4-carboxylic acid methyl ester 
• 14774-37-9 (tetrahydro-2H-pyran-4-yl)methanol 
• 67643-17-8 4-hydroxy-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 67643-16-7 2-amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile 
• 1438382-15-0 3-(aminomethyl)-4-methoxy-6-methylpyridin-2(1H)-one 
• 1450658-95-3 2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxylic acid 
• 1450658-81-7 methyl 2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxylate 
• 1450658-66-8 (Z)-methyl 2-(2-bromophenyl)-3-((1-(tetrahydro-2H-pyran-4-yl)ethyl)amino)but-2-enoate 
• 57486-69-8 methyl 2-(2-bromophenyl)acetate 
• 1243144-97-9 methyl 2-(2-bromophenyl)-3-hydroxybut-2-enoate 
• 854697-78-2 1-(tetrahydro-2H-pyran-4-yl)ethanamine 
• 1350711-79-3 4-(1-azidoethyl)tetrahydro-2H-pyran 
• 1202528-73-1 1-(tetrahydro-2H-pyran-4-yl)ethyl methanesulfonate 
• 66956-74-9 1-(tetrahydro-2H-pyran-4-yl)ethan-1-ol 

Downstream Products

• 1802175-06-9 (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide 
• 1802175-06-9 (S)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide 

Relevant academic research and scientific papers

SUBSTITUTED BENZENE AND 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS

The present invention relates to substituted benzene compounds and bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.

MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents having the structural Formula (II) for modulating histone methyl modifying enzymes, compositions and uses thereof for instance as anti-cancer agents are provided herein.