67643-16-7

Basic information

• Product Name: 4H-Pyran-3-carbonitrile,2-amino-6-methyl-4-oxo-(9CI)
• Synonyms: 4H-Pyran-3-carbonitrile,2-amino-6-methyl-4-oxo-(9CI);4H-Pyran-3-carbonitrile, 2-aMino-6-Methyl-4-oxo-;2-Amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile
• CAS NO: 67643-16-7
• Molecular Formula: C₇H₆N₂O₂
• Molecular Weight: 150.13474
• Product Categories: AMINEPRIMARY
• Mol File: 67643-16-7.mol
• Article Data: 16

Chemical Properties

• Melting Point: 275 °C (decomp)
• Boiling Point: 381℃
• Flash Point: 184℃
• Appearance: /
• Density: 1.32
• PKA: 0.03±0.40(Predicted)
• CAS DataBase Reference: 4H-Pyran-3-carbonitrile,2-amino-6-methyl-4-oxo-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyran-3-carbonitrile,2-amino-6-methyl-4-oxo-(9CI)(67643-16-7)
• EPA Substance Registry System: 4H-Pyran-3-carbonitrile,2-amino-6-methyl-4-oxo-(9CI)(67643-16-7)

Safety Data

• Hazardous Substances Data: 67643-16-7(Hazardous Substances Data)

Usage

General Description

4H-Pyran-3-carbonitrile, 2-amino-6-methyl-4-oxo (9CI) is a chemical compound with the molecular formula C8H7N3O. It is a member of the pyran-3-carbonitrile family and contains an amino group, methyl group, and oxo group. 4H-Pyran-3-carbonitrile,2-amino-6-methyl-4-oxo-(9CI) has potential applications in organic synthesis, pharmaceuticals, and chemical research due to its unique structure and reactivity. Its precise properties and potential uses would require further study and analysis, making it an interesting target for future research and development.

Upstream product

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Downstream Products

• 1621862-70-1 CPI-1205 
• 1450655-12-5 (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(piperidin-4-yl)ethyl)-1H-indole-3-carboxamide 
• 1802175-06-9 (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide 
• 1802175-06-9 (S)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide 
• 1450654-49-5 N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide 
• 1438382-15-0 3-(aminomethyl)-4-methoxy-6-methylpyridin-2(1H)-one 
• 1802175-07-0 CPI-169 
• 1450662-06-2 ((2,4-dimethoxy-6-methylpyridin-3-yl)methyl)carbamic acid tert-butyl ester 
• 1450662-05-1 2,4-dimethoxy-6-methylnicotinonitrile 
• 1615710-53-6 N-((2-chloro-6-methyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide 

Relevant articles and documents

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

Zeste enhancer homolog 2 (EZH2) is highly expressed in various malignant tumors, which could silence tumor suppressor genes via trimethylation of H3K27. Herein was first reported a novel series of pyrrole-3-carboxamide derivatives carrying a pyridone fragment as EZH2 inhibitors. By combining computational modeling, in vitro cellular assays and further rational structure-activity relationship exploration and optimization, compound DM-01 showed powerful inhibition towards EZH2. DM-01 was found to have significant ability to reduce the cellular H3K27me3 level in K562 cells in the Western blot test. Meanwhile, our data showed that knockdown EZH2 in A549 cells resulted in a decrease of cell sensitivity to DM-01 at 50 and 100 μM. DM-01 could also increase the transcription expression of DIRAS3 in a dose-dependent manner, a tumor suppressor in the downstream of EZH2, suggesting it was worth investigating further as a lead compound.

1,5,7-TRISUBSTITUTED ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN MEDICINES

The present disclosure relates to 1,5,7-trisubstituted isoquinoline derivatives, their preparation and pharmaceutical use. In particular, the present disclosure discloses a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate or prodrug thereof, and a preparation method and use thereof. The definitions of the groups in the formula can be found in the specification and claims.

SULFONYL-SUBSTITUTED BENZOHETEROCYCLIC DERIVATIVE, PREPARATION METHOD AND MEDICAL USE THEREOF

The present invention relates to a sulfonyl-substituted benzoheterocyclic derivative, a preparation method and medical use thereof. Particularly, disclosed is a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, and a preparation method and application thereof. The definition of each group in the formula can be found in the specification and the claims.