1450662-05-1

Basic information

• Product Name: 2,4-dimethoxy-6-methylnicotinonitrile
• Synonyms: 2,4-dimethoxy-6-methylnicotinonitrile
• CAS NO: 1450662-05-1
• Molecular Formula: C₉H₁₀N₂O₂
• Molecular Weight: 178.1879
• Mol File: 1450662-05-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,4-dimethoxy-6-methylnicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dimethoxy-6-methylnicotinonitrile(1450662-05-1)
• EPA Substance Registry System: 2,4-dimethoxy-6-methylnicotinonitrile(1450662-05-1)

Safety Data

• Hazardous Substances Data: 1450662-05-1(Hazardous Substances Data)

Usage

Class

Nicotinic acid derivative

Use

Intermediate in the synthesis of pharmaceutical products

Chemical properties

Two methoxy groups and one methyl group attached to the nicotinonitrile ring

Biological activities

Anti-inflammatory and anti-cancer properties

Potential

Candidate for the development of new drugs

Versatility

Building block for the synthesis of novel compounds with therapeutic applications

Upstream product

• 67-56-1 methanol 
• 38367-36-1 2,4-dichloro-6-methyl-3-pyridinecarbonitrile 
• 124-41-4 sodium methylate 
• 67643-17-8 2,4-dihydroxy-6-methylnicotinonitrile 
• 67643-16-7 2-amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile 
• 1615716-05-6 2-chloro-4-((4-methoxybenzyl)oxy)-6-methylnicotinonitrile 

Downstream Products

• 1450662-06-2 ((2,4-dimethoxy-6-methylpyridin-3-yl)methyl)carbamic acid tert-butyl ester 
• 1621862-70-1 CPI-1205 
• 1450655-12-5 (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(piperidin-4-yl)ethyl)-1H-indole-3-carboxamide 
• 1438382-15-0 3-(aminomethyl)-4-methoxy-6-methylpyridin-2(1H)-one 
• 1802175-07-0 CPI-169 
• 1802175-06-9 (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide 

Relevant articles and documents

5-Hydroxyindole-based EZH2 inhibitors assembled via TCCA-catalyzed condensation and Nenitzescu reactions

5-Hydroxyindole derivatives have various demonstrated biological activities. Herein, we used 5-hydroxyindole as a synthetic starting point for structural alterations in a combinatorial process to synthesize 22 different compounds with EZH2 inhibitor pharmacophores. A series of 5-hydroxyindole-derived compounds were screened inhibitory activities against K562 cells. According to molecular modeling and in vitro biological activity assays, the preliminary structure-activity relationship was summarized. Compound L–04 improved both the H3K27Me3 reduction and antiproliferation parameters (IC50 = 52.6 μM). These findings revealed that compound L–04 is worthy of consideration as a lead compound to design more potent EZH2 inhibitors. During the preparation of compounds, we discovered that trichloroisocyanuric acid (TCCA) is a novel catalyst which demonstrates condensation-promoting effects. To gain insight into the reaction, in situ React IR technology was used to confirm the reactivity. Different amines were condensed in high yields with β-diketones or β-ketoesters in the presence of TCCA to afford the corresponding products in a short time (10~20 min), which displayed some advantages and provided an alternative condensation strategy.

IMIDAZOPYRIDINE EZH2 INHIBITORS

The present invention relates to imidazopyridines of general formula (I), to a method for their preparation, to intermediates for their preparation, to pharmaceutical compositions comprising at least one of those compounds, and to the use thereof.

INDOLE DERIVATIVES AS MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents of formulas (l)/(ll)/(lll) for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.