1450662-05-1

Basic information

• Product Name: 2,4-dimethoxy-6-methylnicotinonitrile
• Synonyms: 2,4-dimethoxy-6-methylnicotinonitrile
• CAS NO: 1450662-05-1
• Molecular Formula: C₉H₁₀N₂O₂
• Molecular Weight: 178.1879
• Mol File: 1450662-05-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2,4-dimethoxy-6-methylnicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dimethoxy-6-methylnicotinonitrile(1450662-05-1)
• EPA Substance Registry System: 2,4-dimethoxy-6-methylnicotinonitrile(1450662-05-1)

Safety Data

• Hazardous Substances Data: 1450662-05-1(Hazardous Substances Data)

Usage

Class

Nicotinic acid derivative

Use

Intermediate in the synthesis of pharmaceutical products

Chemical properties

Two methoxy groups and one methyl group attached to the nicotinonitrile ring

Biological activities

Anti-inflammatory and anti-cancer properties

Potential

Candidate for the development of new drugs

Versatility

Building block for the synthesis of novel compounds with therapeutic applications

Upstream product

• 67-56-1 methanol 
• 38367-36-1 2,4-dichloro-6-methyl-3-pyridinecarbonitrile 
• 124-41-4 sodium methylate 
• 67643-17-8 2,4-dihydroxy-6-methylnicotinonitrile 
• 67643-16-7 2-amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile 
• 1615716-05-6 2-chloro-4-((4-methoxybenzyl)oxy)-6-methylnicotinonitrile 

Downstream Products

• 1450662-06-2 ((2,4-dimethoxy-6-methylpyridin-3-yl)methyl)carbamic acid tert-butyl ester 
• 1450655-12-5 (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(piperidin-4-yl)ethyl)-1H-indole-3-carboxamide 
• 1621862-70-1 CPI-1205 
• 1438382-15-0 3-(aminomethyl)-4-methoxy-6-methylpyridin-2(1H)-one 
• 1802175-07-0 CPI-169 
• 1802175-06-9 (R)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(tetrahydro-2H-pyran-4-yl)ethyl)-1H-indole-3-carboxamide 

Relevant articles and documents

Design, synthesis and biological activities of pyrrole-3-carboxamide derivatives as EZH2 (enhancer of zeste homologue 2) inhibitors and anticancer agents

Zeste enhancer homolog 2 (EZH2) is highly expressed in various malignant tumors, which could silence tumor suppressor genes via trimethylation of H3K27. Herein was first reported a novel series of pyrrole-3-carboxamide derivatives carrying a pyridone fragment as EZH2 inhibitors. By combining computational modeling, in vitro cellular assays and further rational structure-activity relationship exploration and optimization, compound DM-01 showed powerful inhibition towards EZH2. DM-01 was found to have significant ability to reduce the cellular H3K27me3 level in K562 cells in the Western blot test. Meanwhile, our data showed that knockdown EZH2 in A549 cells resulted in a decrease of cell sensitivity to DM-01 at 50 and 100 μM. DM-01 could also increase the transcription expression of DIRAS3 in a dose-dependent manner, a tumor suppressor in the downstream of EZH2, suggesting it was worth investigating further as a lead compound.

Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitabl

Polycomb repressive complex 2 (PRC2) has been shown to play a major role in transcriptional silencing in part by installing methylation marks on lysine 27 of histone 3. Dysregulation of PRC2 function correlates with certain malignancies and poor prognosis

INDOLE DERIVATIVES AS MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF

Agents of formulas (l)/(ll)/(lll) for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.