14527-44-7

Usage

Uses

Used in Food and Beverage Industry:
Methyl 5-thiazolecarboxylate is used as a flavoring agent for its distinctive fruity, nutty, and meaty odor, enhancing the taste and aroma of various food products and beverages.
Used in Pharmaceutical Synthesis:
Methyl 5-thiazolecarboxylate is used as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Production:
Methyl 5-thiazolecarboxylate is utilized in the production of agrochemicals, playing a role in the development of pesticides, herbicides, and other agricultural chemicals to improve crop protection and yield.
Used in Fine Chemicals Synthesis:
Methyl 5-thiazolecarboxylate is used in the synthesis of various fine chemicals, including fragrances, dyes, and other specialty chemicals, due to its versatile reactivity and potential biological activity.

InChI:InChI=1/C5H5NO2S/c1-8-5(7)4-2-9-3-6-4/h2-3H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 14527-41-4 thiazole-5-carboxylic acid 
• 6633-61-0 methyl 2-aminothiazole-5-carboxylate 
• 110-46-3 isopentyl nitrite 
• 463-04-7 n-Amyl nitrite 
• 20656-61-5 methyl 2-chloro-3-oxopropionate 
• 115-08-2 thiocarboxamide 

Downstream Products

• 38585-74-9 thiazol-5-yl-methanol 
• 1593701-07-5 methyl 2-(5-(4-methoxybenzyloxy)pyridin-2-yl)thiazole-5-carboxylate 
• 1261080-59-4 methyl 2-acetylthiazole-5-carboxylate 

Relevant academic research and scientific papers

Flow hydrodediazoniation of aromatic heterocycles

Continuous flow processing was applied for the rapid replacement of an aromatic amino group with a hydride. The approach was applied to a range of aromatic heterocycles, confirming the wide scope and substituent-tolerance of the processes. Flow equipment was utilized and the process optimised to overcome the problematically-unstable intermediates that have restricted yields in previous studies relying on batch procedures. Various common organic solvents were investigated as potential hydride sources. The approach has allowed key structures, such as amino-pyrazoles and aminopyridines, to be deaminated in good yield using a purely organic-soluble system.

BROADSPECTRUM SUBSTITUTED BENZISOXAZOLE SULFONAMIDE HIV PROTEASE INHIBITORS

The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs esters and metabolites thereof.It further relates to their use as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. It also concerns combinations thereof with another anti-retroviral agent, and to their use in assays as reference compounds or as reagents.

Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors

PCT No. PCT/US94/09139 Sec. 371 Date Jan. 24, 1996 Sec. 102(e) Date Jan. 24, 1996 PCT Filed Aug. 23, 1994 PCT Pub. No. WO95/06030 PCT Pub. Date Mar. 2, 1995The invention relates to sulfonamide-containing hydroxyethylamine protease inhibitor compounds, their process of making, composition and method of use for inhibiting retroviral proteases such as human immunodeficiency virus.

Thiazole derivatives

The invention provides thiazole derivatives of general formula I; STR1 or an acid-addition salt or metal salt complex thereof, in which R represents an optionally substituted aryl group; R1 represents a hydrogen atom or an optionally substituted alkyl, alkenyl or alkynyl group; R2 represents a hydrogen or halogen atom or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, hydroxyl, cyano, nitro, amino, alkylamino, dialkylamino or morpholine group; X represents an oxygen or sulphur atom, a carbonyl group or a group --CR4 R5 -- where R4 and R5 independently represent a hydrogen atom or an alkoxy group; Y represents an oxygen or sulphur atom; n represents an integer from 0 to 6; m is 0 or 1; and Z represents a phenyl group; processes for their preparation; compositions containing such compounds and their use as fungicides.