1452816-01-1Relevant articles and documents
A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues
Brindisi, Margherita,Gemma, Sandra,Alfano, Gloria,Kshirsagar, Giridhar,Novellino, Ettore,Campiani, Giuseppe,Butini, Stefania
, p. 5387 - 5390 (2013/09/12)
We developed a novel and convenient stereoselective path for the preparation of pyrrolo-1,5-benzoxazepinones (PBOs). This innovative route envisaged the employment of (-)-menthol as convenient chiral auxiliary and a key SNAr for the stereoselective preparation of a tertiary aryl-alkyl ether. As a further advancement, we exploited this newly conceived synthetic route for the preparation of 2-substituted PBO analogues to either undergo biological evaluation themselves or give access to a variety of further functionalization options.