1258305-05-3

Basic information

• Product Name: α-ethyl-α-hydroxy-4-methylbenzeneacetic acid
• Synonyms: α-ethyl-α-hydroxy-4-methylbenzeneacetic acid
• CAS NO: 1258305-05-3
• Molecular Weight: 194.23
• Mol File: 1258305-05-3.mol

Chemical Properties

• CAS DataBase Reference: α-ethyl-α-hydroxy-4-methylbenzeneacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: α-ethyl-α-hydroxy-4-methylbenzeneacetic acid(1258305-05-3)
• EPA Substance Registry System: α-ethyl-α-hydroxy-4-methylbenzeneacetic acid(1258305-05-3)

Safety Data

• Hazardous Substances Data: 1258305-05-3(Hazardous Substances Data)

Upstream product

• 120926-96-7 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methylphenyl)(oxo)acetate 
• 5524-56-1 ethyl 2-p-tolyl-2-oxoacetate 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 108-88-3 toluene 
• 124-38-9 carbon dioxide 
• 5337-93-9 4'-methylpropiophenone 
• 1257420-16-8 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (2R)-2-hydroxy-2-(4-methylphenyl)butanoate 

Downstream Products

• 1452815-88-1 C₁₂H₁₆O₃ 
• 1452815-97-2 C₁₈H₁₉NO₅ 
• 1452815-89-2 C₁₇H₁₇NO₂ 
• 1452815-90-5 C₂₂H₂₂N₂O₅ 
• 1452815-91-6 C₂₂H₂₄N₂O₃ 
• 1452815-92-7 C₂₂H₂₃NO₃ 
• 1452815-87-0 (R)-6-ethyl-6-(p-tolyl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one 
• 1452815-93-8 C₂₂H₂₂INO₃ 
• 1452815-94-9 C₂₂H₂₂BrNO₃ 
• 1452816-01-1 (R)-6-ethyl-2-iodo-6-(p-tolyl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one 
• 1452816-02-2 (R)-2-bromo-6-ethyl-6-(p-tolyl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one 
• 1452815-98-3 C₂₁H₂₁NO₃ 
• 1452815-99-4 C₂₁H₂₀INO₃ 
• 1452816-00-0 C₂₁H₂₀BrNO₃ 

Relevant articles and documents

A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues

We developed a novel and convenient stereoselective path for the preparation of pyrrolo-1,5-benzoxazepinones (PBOs). This innovative route envisaged the employment of (-)-menthol as convenient chiral auxiliary and a key SNAr for the stereoselective preparation of a tertiary aryl-alkyl ether. As a further advancement, we exploited this newly conceived synthetic route for the preparation of 2-substituted PBO analogues to either undergo biological evaluation themselves or give access to a variety of further functionalization options.

Alkaloid induced asymmetric electrocarboxylation of 4-methylpropiophenone

The alkaloid-induced electrocarboxylation of 4-methylpropiophenone is examined in mild conditions. Comparative studies with several inductors indicate that the efficient enantiodiscrimination of the electrocarboxylation depends on the nucleophilic quinucl

The stereoselective synthesis of 2-aryl-2-hydroxybutanoic acid via menthyl chiral auxiliaries

In the presence of titanium(IV) tetraethoxide ((EtO)4Ti), menthyl arylglyoxylates are prepared by transesterification of ethyl arylglyoxylates and natural (-)-(1R,2S,5R)-menthol. Using menthyl as a chiral auxiliary, the corresponding novel (R)-menthyl 2-aryl-2-hydroxybutanoates are synthesized by the addition of Et2Zn with menthyl arylglyoxylates. The structures of the products are characterized by IR and 1H- and 13C-NMR spectroscopy, mass spectrometry, and elemental analysis. The diastereoselectivities are analyzed by HPLC. The addition reactions are completed with good yields and high diastereoisomeric excess (de up to 95%), and, after hydrolysis, the (R)-2-aryl-2-hydroxybutanoic acids are obtained with high optical purities.