1452816-02-2

Basic information

• Product Name: (R)-2-bromo-6-ethyl-6-(p-tolyl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one
• Synonyms: (R)-2-bromo-6-ethyl-6-(p-tolyl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one
• CAS NO: 1452816-02-2
• Molecular Weight: 396.283
• Mol File: 1452816-02-2.mol

Chemical Properties

• CAS DataBase Reference: (R)-2-bromo-6-ethyl-6-(p-tolyl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-bromo-6-ethyl-6-(p-tolyl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one(1452816-02-2)
• EPA Substance Registry System: (R)-2-bromo-6-ethyl-6-(p-tolyl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one(1452816-02-2)

Safety Data

• Hazardous Substances Data: 1452816-02-2(Hazardous Substances Data)

Upstream product

• 1452815-88-1 C₁₂H₁₆O₃ 
• 1257420-16-8 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (2R)-2-hydroxy-2-(4-methylphenyl)butanoate 
• 1452816-00-0 C₂₁H₂₀BrNO₃ 
• 120926-96-7 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (4-methylphenyl)(oxo)acetate 
• 5524-56-1 ethyl 2-p-tolyl-2-oxoacetate 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 1258305-05-3 α-ethyl-α-hydroxy-4-methylbenzeneacetic acid 
• 1452815-94-9 C₂₂H₂₂BrNO₃ 
• 108-88-3 toluene 
• 1452815-91-6 C₂₂H₂₄N₂O₃ 
• 1452815-90-5 C₂₂H₂₂N₂O₅ 

Relevant articles and documents

A stereoselective route to 6-substituted pyrrolo-1,5-benzoxazepinones and their analogues

We developed a novel and convenient stereoselective path for the preparation of pyrrolo-1,5-benzoxazepinones (PBOs). This innovative route envisaged the employment of (-)-menthol as convenient chiral auxiliary and a key SNAr for the stereoselective preparation of a tertiary aryl-alkyl ether. As a further advancement, we exploited this newly conceived synthetic route for the preparation of 2-substituted PBO analogues to either undergo biological evaluation themselves or give access to a variety of further functionalization options.