1453176-99-2

Basic information

• Product Name: C₁₇H₁₁ClFNO
• Synonyms: C₁₇H₁₁ClFNO
• CAS NO: 1453176-99-2
• Molecular Weight: 299.732
• Mol File: 1453176-99-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₁ClFNO(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₁ClFNO(1453176-99-2)
• EPA Substance Registry System: C₁₇H₁₁ClFNO(1453176-99-2)

Safety Data

• Hazardous Substances Data: 1453176-99-2(Hazardous Substances Data)

Upstream product

• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 2146-07-8 p-fluoroaniline hydrochloride 
• 351-09-7 N-(4-fluorophenyl)-2-(hydroxyimino) acetamide 
• 18060-42-9 6-fluoro-2-p-tolylquinoline-4-carboxylic acid 

Relevant articles and documents

Design, synthesis and antitumour activity of bisquinoline derivatives connected by 4-oxy-3-fluoroaniline moiety

A series of novel bisquinoline derivatives connected by a 4-oxy-3-fluoroaniline moiety were synthesized and evaluated for their in vitro antitumour activities against a panel of five cancer cell lines (H460, HT-29, MKN-45, U87MG, and SMMC-7721). Most of compounds tested showed a potent activity and high selectivity towards the H460 and MKN-45 cell lines. Among the compounds tested, six (15d, 15e, 15m, 15n, 16a, and 16i) were further examined for their c-Met kinase activity; the compounds showed high efficacy with IC 50 values in the single-digit nM range. An analysis of structure-activity relationships indicated that an unsubstituted or a halogen-substituted phenyl ring on the 2-arylquinoline-4-carboxamide moiety was favourable for antitumour activity.