18060-42-9

Basic information

• Product Name: 6-fluoro-2-(4-methylphenyl)quinoline-4-carboxylic acid
• CAS NO: 18060-42-9
• Molecular Formula: C₁₇H₁₂FNO₂
• Molecular Weight: 281.2811
• Mol File: 18060-42-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 466.2°C at 760 mmHg
• Flash Point: 235.8°C
• Density: 1.307g/cm³
• Vapor Pressure: 1.71E-09mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 6-fluoro-2-(4-methylphenyl)quinoline-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-2-(4-methylphenyl)quinoline-4-carboxylic acid(18060-42-9)
• EPA Substance Registry System: 6-fluoro-2-(4-methylphenyl)quinoline-4-carboxylic acid(18060-42-9)

Safety Data

• Hazardous Substances Data: 18060-42-9(Hazardous Substances Data)

Usage

General Description

6-fluoro-2-(4-methylphenyl)quinoline-4-carboxylic acid is a chemical compound with the molecular formula C18H13NO2F. It is a fluoro-substituted quinoline derivative with a carboxylic acid group, and a methylphenyl moiety. 6-fluoro-2-(4-methylphenyl)quinoline-4-carboxylic acid has potential pharmacological and biological activities and may be used as a building block or intermediate in the synthesis of pharmaceuticals or agrochemicals. It is important to handle this chemical with caution and follow safety guidelines when working with it in laboratory settings.

Upstream product

• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 122-00-9 para-methylacetophenone 
• 2146-07-8 p-fluoroaniline hydrochloride 
• 351-09-7 N-(4-fluorophenyl)-2-(hydroxyimino) acetamide 

Downstream Products

• 1453176-99-2 C₁₇H₁₁ClFNO 

Relevant articles and documents

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

The antiplasmodial activity, DMPK properties, and efficacy of a series of quinoline-4-carboxamides are described. This series was identified from a phenotypic screen against the blood stage of Plasmodium falciparum (3D7) and displayed moderate potency but with suboptimal physicochemical properties and poor microsomal stability. The screening hit (1, EC50 = 120 nM) was optimized to lead molecules with low nanomolar in vitro potency. Improvement of the pharmacokinetic profile led to several compounds showing excellent oral efficacy in the P. berghei malaria mouse model with ED90 values below 1 mg/kg when dosed orally for 4 days. The favorable potency, selectivity, DMPK properties, and efficacy coupled with a novel mechanism of action, inhibition of translation elongation factor 2 (PfEF2), led to progression of 2 (DDD107498) to preclinical development.

Design, synthesis and antitumour activity of bisquinoline derivatives connected by 4-oxy-3-fluoroaniline moiety

A series of novel bisquinoline derivatives connected by a 4-oxy-3-fluoroaniline moiety were synthesized and evaluated for their in vitro antitumour activities against a panel of five cancer cell lines (H460, HT-29, MKN-45, U87MG, and SMMC-7721). Most of compounds tested showed a potent activity and high selectivity towards the H460 and MKN-45 cell lines. Among the compounds tested, six (15d, 15e, 15m, 15n, 16a, and 16i) were further examined for their c-Met kinase activity; the compounds showed high efficacy with IC 50 values in the single-digit nM range. An analysis of structure-activity relationships indicated that an unsubstituted or a halogen-substituted phenyl ring on the 2-arylquinoline-4-carboxamide moiety was favourable for antitumour activity.