14537-64-5Relevant academic research and scientific papers
Versatile strategies for the solid phase synthesis of small heterocyclic scaffolds: [1,3,4]-Thiadiazoles and [1,3,4]-oxadiazoles
Severinsen, Rune,Kilburn, John Paul,Lau, Jesper F.
, p. 5565 - 5575 (2007/10/03)
New robust protocols for the solid phase synthesis of 5-alkylthio-, 5-alkyl/aryl-, and 5-acylamino-2-alkylamino-[1,3,4]-thiadiazoles are described based on a common resin bound thiosemicarbazide. A protocol for the solid phase synthesis of 2-alkyl/aryl-amino-5-alkylamino-[1,3,4]-oxadiazoles from a resin bound semicarbazide is likewise reported. The protocols have been verified by the preparation of four small libraries that all gave products in good to excellent yields and purity.
Reactions of Sulfur Monochloride with some Aromatic Aldehyde Semicarbazones and Thiosemicarbazones: New Syntheses of Substituted 2,4-Dihydro-1,2,4-triazol-3-ones, 2,4-Dihydro-1,2,4-triazole-3-thiones and 2-Amino-1,3,4-oxadiazoles
Milcent, Rene,Nguyen, Thu-Huong
, p. 881 - 883 (2007/10/02)
Treatment of various substituted semicarbazones of aromatic aldehydes with sulfur monochloride yields the corresponding substituted 2,4-dihydro-1,2,4-triazol-3-ones.With thiosemicarbazones, the products are derivatives either of the 2-amino-1,3,4-thiadiaz
