14542-16-6

Basic information

• Product Name: 4-Methyl-1,3-thiazole-2-carboxylic acid
• Synonyms: 4-Methyl-1,3-thiazole-2-carboxylic acid;4-Methylthiazole-2-carboxylic acid;methyl 4-methyl-1,3-thiazole-2-carboxylate;2-Carboxy-4-methyl-1,3-thiazole;4-Methyl-2-thiazole-carboxylic acid
• CAS NO: 14542-16-6
• Molecular Formula: C₅H₅NO₂S
• Molecular Weight: 143.1637
• Product Categories: Carboxylic Acids;Thiazoles, Isothiazoles &Benzothiazoles;Carboxylic Acids;Thiazoles, Isothiazoles & Benzothiazoles
• Mol File: 14542-16-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 99 °C
• Boiling Point: 317.135 °C at 760 mmHg
• Flash Point: 145.598 °C
• Appearance: White/Crystalline Powder
• Density: 1.418 g/cm³
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 0.55±0.10(Predicted)
• CAS DataBase Reference: 4-Methyl-1,3-thiazole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-1,3-thiazole-2-carboxylic acid(14542-16-6)
• EPA Substance Registry System: 4-Methyl-1,3-thiazole-2-carboxylic acid(14542-16-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 14542-16-6(Hazardous Substances Data)

Usage

General Description

4-Methyl-1,3-thiazole-2-carboxylic acid is a chemical compound with the molecular formula C6H7NO2S. It is a heterocyclic compound with a thiazole ring and a carboxylic acid group. 4-Methyl-1,3-thiazole-2-carboxylic acid is often used as a building block in organic synthesis and medicinal chemistry, particularly in the development of pharmaceutical drugs. It has been studied for its potential anti-bacterial and anti-inflammatory properties, and has also been investigated as an ingredient in the synthesis of various bioactive compounds. Overall, 4-Methyl-1,3-thiazole-2-carboxylic acid is an important compound in the field of organic chemistry with potential applications in pharmaceutical research and drug development.

Upstream product

• 24622-44-4 (E)-4-methyl-2-styrylthiazole 
• 693-95-8 4-Methylthiazole 
• 124-38-9 carbon dioxide 
• 7210-73-3 4-Methylthiazol-2-carbonsaeure-ethylester 
• 7586-99-4 2-(α-hydroxyethyl)-4-methylthiazole 
• 13750-68-0 4-methyl-thiazole-2-carbaldehyde 
• 541-58-2 2,4-dimethylthiazole 

Downstream Products

• 1628847-80-2 N-((1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-2'-(morpholinomethyl)biphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexyl)-4-methylthiazole-2-carboxamide trifluoroacetic acid salt 
• 1446003-98-0 C₃₉H₆₂N₄O₁₅S 
• 79312-42-8 C₅H₄ClNOS 
• 100516-76-5 4-methyl-1,3-thiazole-2-carbohydrazide 
• 14542-15-5 methyl 4-methyl-1,3-thiazole-2-carboxylate 
• 693-95-8 4-Methylthiazole 

Relevant articles and documents

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Discovery of functionally selective 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazines as GABAA receptor agonists at the α3 subunit

We have previously identified the 7,8,9,10-tetrahydro-7,10-ethano-1,2,4- triazolo[3,4-a]phthalazine (1) as a potent partial agonist for the 0.3 receptor subtype with 5-fold selectivity in binding affinity over α1. This paper describes a detailed investigation of the substituents on this core structure at both the 3- and 6-positions. Despite evaluating a wide range of groups, the maximum selectivity that could be achieved in terms of affinity for the α3 subtype over the α1 subtype was 12-fold (for 57). Although most analogues showed no selectivity in terms of efficacy, some did show partial agonism at α1 and antagonism at α3 (e.g., 25 and 75). However, two analogues tested (93 and 96), both with triazole substituents in the 6-position, showed significantly higher efficacy for the α3 subtype over the α1 subtype. This was the first indication that selectivity in efficacy in the required direction could be achieved in this series.