7210-73-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Methylthiazole-2-carboxylic Acid Ethylester is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be incorporated into drug molecules, potentially enhancing their therapeutic properties and effectiveness.
Used in Drug Development:
In the field of drug development, 4-Methylthiazole-2-carboxylic Acid Ethylester serves as a key building block for the creation of new drug candidates. Its incorporation into drug molecules can lead to the discovery of novel therapeutic agents with improved pharmacological profiles.
Used in Research and Development:
4-Methylthiazole-2-carboxylic Acid Ethylester is also utilized in research and development settings, where scientists explore its potential applications and interactions with biological systems. This can lead to a better understanding of its properties and possible uses in medicine and other fields.

Upstream product

• 16982-21-1 ethyl 2-amino-2-thioxoacetate 
• 78-95-5 chloroacetone 
• 598-31-2 1-bromoacetone 
• 67-64-1 acetone 

Downstream Products

• 14542-16-6 4-methyl-1,3-thiazole-2-carboxylic acid 
• 100516-76-5 4-methyl-1,3-thiazole-2-carbohydrazide 
• 883-34-1 3-methyl-5-phenylimidazo<5,1-b>thiazole 
• 13750-68-0 4-methyl-thiazole-2-carbaldehyde 
• 103989-44-2 N-benzenesulfonyl-N'-(4-methyl-thiazole-2-carbonyl)-hydrazine 
• 1429560-37-1 2-(7-(4-methoxybenzyl)-8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-4-methylthiazole 
• 1429560-43-9 (8-methyl-3-(4-methylthiazol-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)(4-(thiophen-2-yl)phenyl)methanone 
• 1610737-03-5 N-((1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)biphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexyl)-4-methylthiazole-2-carboxamide 
• 14542-15-5 methyl 4-methyl-1,3-thiazole-2-carboxylate 
• 16914-25-3 2-ethoxycarbonyl-3,4-dimethyl-thiazolium; toluene-4-sulfonate 
• 16914-23-1 2-Ethoxycarbonyl-3,4-dimethyl-thiazolium-(2,4-dinitro-benzolsulfonat) 
• 13750-63-5 (4-methylthiazol-2-yl)-methanol 
• 79247-80-6 ethyl 5-bromo-4-methylthiazole-2-carboxylate 
• 78502-75-7 4-Dibrommethyl-2-thiazolcarbonsaeure-ethylester 

Relevant academic research and scientific papers

Relationship between mechanochromic behavior and crystal structures in donor-π-acceptor compounds consisted of aromatic rings with ester moiety as an acceptor

We investigated the mechanochromic behavior of donor-π-acceptor compounds which consisted of diphenylaminophenylacetylene as a donor-π moiety and (hetero)aromatic ring bearing ester as an acceptor. The compounds with dicyanobenzoic ester gave the bathochr

Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists

We described here the synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as potential mGluR5 antagonists. We found that a series of thiazole derivatives 6 showed better inhibitory activity against mGluR5. Compounds 6bc and 6bj have been identified as potent antagonists (IC50 = 274 and 159 nM) showing excellent in vitro stability profile. Molecular docking study using the crystal structure of mGluR5 revealed that our compounds 6bc and 6bj fit the allosteric binding site of mavoglurant well.

5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof wherein A is hydrogen, C1-4alkyl, C3-6cycloalkyl, C1-3alkoxy, C1-3alkoxy C1-4alkyl, C1-2fluoroalkyl, halogen, NR6 R7, optionally substituted heteroaryl (Het), or optionally substituted phenyl, and R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The compounds or salts are thought to modulate P2X7 receptor function and to be capable of antagonizing the effects of ATP at the P2X7 receptor. The invention also provides the use of the compound or salt in the treatment or prophylaxis of, for example, inflammatory pain, neuropathic pain, visceral pain, rheumatoid arthritis, osteoarthritis or neurodegenerative disorders.

THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES

Thiazole amides, imidazole amides and related analogues of the Formula: are provided, in which variables are as described herein. Such compounds may be used to modulate ligand binding to histamine H3 receptors in vivo or in vitro, and are particularly use

An Infrared Study of Rotational Isomerism in Thiazole-2-carboxylates

A series of alkyl thiazole-2-carboxylates containing a range of substituents at the 4- and 5-positions has been prepared.Solutions of these esters (mostly new compounds) show well resolved doublets in the i.r.C=O region which arise from rotational isomers.The higher wavenumber components are assigned to the more polar carbonyl O,S-anti-s-trans-rotamers and the lower wavenumber components to the carbonyl O,S-syn-s-trans-forms.Small, but systematic, differences between the methyl esters are noted.