1454848-65-7

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a potential candidate for the development of new drugs.
Used in Chemical Research:
Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate is used as a research compound in the field of organic chemistry. Its properties and reactivity can be studied to gain insights into the behavior of similar compounds and to develop new synthetic methods.
Used in Material Science:
Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate is used as a building block in the development of new materials with specific properties. Its incorporation into polymers or other materials can lead to the creation of novel materials with potential applications in various industries.

Upstream product

• 67-56-1 methanol 
• 796729-03-8 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid 
• 98262-66-9 3a,4,5,6-tetrahydro-3-oxo-3H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium ylide 
• 922-67-8 propynoic acid methyl ester 

Downstream Products

• 796729-03-8 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid 
• 796729-10-7 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid 
• 623564-45-4 (5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-2-yl)methanol 

Relevant academic research and scientific papers

MACROCYCLIC COMPOUNDS

The present application discloses compounds of Formula (I). Such compounds, pharmaceutically acceptable salts and compositions thereof, are inhibitors of Mcl-1 proteins and are useful in treating diseases and conditions characterized by excessive cellular proliferation such as cancer.

MACROCYCLIC COMPOUNDS

Disclosed are macrocyclic compounds of formula (I) comprising a 2-carboxy indole ring. Such compounds, and their pharmaceutically acceptable salts, are useful as Mcl-1 (myeloid cell leukemia-1) inhibitors. The compounds may be used in treating a disease o

MACROCYCLIC INDOLES AS MCL-1 INHIBITORS

Disclosed is compound of formula I and the pharmaceutically acceptable salts and solvates thereof, wherein R, R1a, R1b, R1h, L1, L2, L3, ?, ?, ? are as defined as set forth in the specification. Disclosed is compound of formula I for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS

Provided are compounds represented by Formula IA: (IA), and the pharmaceutically acceptable salts and solvates thereof, wherein R, R 1a, R 1b, L 1, L 2, L 3, X, A, B and C are as defined as set forth

Big ring indole used as MCL-1 inhibitor

The invention provides a compound represented by a formula (I) and a pharmaceutical salt and solvate thereof. In the formula (I), the definitions of R, R1a, R1b, R1h, L1, L2, and L3 are shown in the description. The invention also provides a compound represented by the formula (I), and the compound can be used to treat disease or disorder related with MCL-1 inhibition, such as cancers.

BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY

The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

9H-PYRIMIDO[4,5-B]INDOLES AND RELATED ANALOGS AS BET BROMODOMAIN INHIBITORS

The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, A, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.