1454848-65-7

Basic information

• Product Name: Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate
• Synonyms: Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate;5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid methyl ester
• CAS NO: 1454848-65-7
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.1772
• Mol File: 1454848-65-7.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate(1454848-65-7)
• EPA Substance Registry System: Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate(1454848-65-7)

Safety Data

• Hazardous Substances Data: 1454848-65-7(Hazardous Substances Data)

Usage

General Description

Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate, also known as Dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid methyl ester or C14H13N3O2 in its molecular form, is a chemical compound and a derivative of pyrrolopyrazole. The exact properties of this particular chemical compound are not broadly studied and documented in scientific literature. Like many other chemical compounds, it's potentially used for different purposes based on its chemical structure. Its molecular weight is approximately 253.27, and it's categorized as an organic compound. Special handling and care are required when interacting with this substance due to potential health hazards.

Upstream product

• 67-56-1 methanol 
• 796729-03-8 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid 
• 98262-66-9 3a,4,5,6-tetrahydro-3-oxo-3H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium ylide 
• 922-67-8 propynoic acid methyl ester 

Downstream Products

• 796729-03-8 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid 
• 796729-10-7 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid 
• 623564-45-4 (5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-2-yl)methanol 

Relevant articles and documents

MACROCYCLIC COMPOUNDS

The present application discloses compounds of Formula (I). Such compounds, pharmaceutically acceptable salts and compositions thereof, are inhibitors of Mcl-1 proteins and are useful in treating diseases and conditions characterized by excessive cellular proliferation such as cancer.

MACROCYCLIC INDOLES AS MCL-1 INHIBITORS

Disclosed is compound of formula I and the pharmaceutically acceptable salts and solvates thereof, wherein R, R1a, R1b, R1h, L1, L2, L3, ?, ?, ? are as defined as set forth in the specification. Disclosed is compound of formula I for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

Big ring indole used as MCL-1 inhibitor

The invention provides a compound represented by a formula (I) and a pharmaceutical salt and solvate thereof. In the formula (I), the definitions of R, R1a, R1b, R1h, L1, L2, and L3 are shown in the description. The invention also provides a compound represented by the formula (I), and the compound can be used to treat disease or disorder related with MCL-1 inhibition, such as cancers.