Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate

Base Information

• Chemical Name: Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate
• CAS No.: 1454848-65-7
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.1772
• Mol file: 1454848-65-7.mol

Synonyms:Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate;5,6-Dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid methyl ester

Chemical Property of Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate

Chemical Property:

• PSA: 44.12000
• LogP: 0.61590
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

Methyl5,6-dihydro-4H-pyrrolo-[1,2-b]pyrazole-2-carboxylate >95% ^*data from reagent suppliers

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Technology Process of Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate

There total 3 articles about Methyl 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methanol (67-56-1) + 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid (796729-03-8) → 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid methyl ester (1454848-65-7)

Guidance literature:

With thionyl chloride; at 0 ℃; for 6h; Reflux;

Reference yield: 24.0%

3a,4,5,6-tetrahydro-3-oxo-3H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium ylide (98262-66-9,86477-05-6) + propynoic acid methyl ester (922-67-8) → 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid methyl ester (1454848-65-7)

Guidance literature:

With 1,2-diethoxyethylene; at 130 ℃;

Reference yield:

3a,4,5,6-tetrahydro-3-oxo-3H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium ylide (98262-66-9,86477-05-6) + propynoic acid methyl ester (922-67-8) → 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid methyl ester (1454848-65-7) + methyl 5, 6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylate

Guidance literature:

In 5,5-dimethyl-1,3-cyclohexadiene; at 125 ℃; for 16h; Overall yield = 35 %; Overall yield = 7.9 g;

upstream raw materials:

3a,4,5,6-tetrahydro-3-oxo-3H-pyrrolo[1,2-c][1,2,3]oxadiazol-7-ium ylide

propynoic acid methyl ester

methanol

5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid

Downstream raw materials:

5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-2-carboxylic acid

5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole-3-carboxylic acid

(5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-2-yl)methanol

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