18070-82-1

Upstream product

• 74-96-4 ethyl bromide 
• 85730-46-7 2-(5-phenyl-1,3,4-thiadiazol-2-yl)acetic acid 
• 86738-35-4 2-(methylsulfonyl)-5-phenyl-1,3,4-thiadiazole 
• 141-78-6 ethyl acetate 
• 2002-03-1 2-amino-5-phenyl-1,3,4-thiadiazole 
• 1456-72-0 2-methyl-5-phenyl-1,3,4-thiadiazole 
• 53645-95-7 2-bromo-5-phenyl-1,3,4-thiadiazole 
• 85730-47-8 diethyl 2-(5-phenyl-1,3,4-thiadiazol-2-yl)malonate 
• 13373-11-0 2-chloro-5-phenyl-[1,3,4]thiadiazole 

Downstream Products

• 85730-48-9 ethyl α-oximino-2-phenyl-1,3,4-thiadiazol-5-ylacetate 
• 139335-30-1 2-(5-Phenyl-[1,3,4]thiadiazol-2-yl)-succinic acid diethyl ester 
• 139335-34-5 3-Ethoxycarbonyl-3-(5-phenyl-[1,3,4]thiadiazol-2-yl)-pentanedioic acid diethyl ester 
• 85730-57-0 C-(5-Phenyl-[1,3,4]thiadiazol-2-yl)-methylamine 
• 85730-49-0 ethyl α-amino-2-phenyl-1,3,4-thiadiazol-5-ylacetate 
• 85730-58-1 (5-Phenyl-[1,3,4]thiadiazol-2-ylmethyl)-carbamic acid 2,2,2-trichloro-ethyl ester 
• 85730-50-3 (5-Phenyl-[1,3,4]thiadiazol-2-yl)-(2,2,2-trichloro-ethoxycarbonylamino)-acetic acid ethyl ester 
• 139335-44-7 3-(5-Phenyl-[1,3,4]thiadiazol-2-yl)-pentanedioic acid 
• 139335-39-0 3-(5-Phenyl-[1,3,4]thiadiazol-2-yl)-propionic acid 

Relevant academic research and scientific papers

α-Heteroarylation of esters, lactones, amides, and lactams by nucleophilic aromatic substitution

A mild and efficient α-heteroarylation of simple esters and amides was developed via nucleophilic aromatic substitution. The choice of NaHMDS in toluene gave the best results. A tandem α-heteroarylation and hydroxylation protocol using air as the oxidant

Synthesis of 2-substituted 1,3,4-thiadiazol-5-ylacetic, propionic, and glutaric acids

1,3,4-Thiadiazol-5-ylacetic, propionic, and glutaric acids (3-5) were synthesized via ethyl 2-substituted 1,3,4-thiadiazol-5-ylacetates (11 and 17) as key intermediates.