1456628-15-1

Basic information

• Product Name: (S)-4-hydroxy-4-(4-methoxyphenyl)butanenitrile
• Synonyms: (S)-4-hydroxy-4-(4-methoxyphenyl)butanenitrile
• CAS NO: 1456628-15-1
• Molecular Weight: 191.23
• Mol File: 1456628-15-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-hydroxy-4-(4-methoxyphenyl)butanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-hydroxy-4-(4-methoxyphenyl)butanenitrile(1456628-15-1)
• EPA Substance Registry System: (S)-4-hydroxy-4-(4-methoxyphenyl)butanenitrile(1456628-15-1)

Safety Data

• Hazardous Substances Data: 1456628-15-1(Hazardous Substances Data)

Upstream product

• 24588-72-5 2-(4-methoxyphenyl)-1,3-dithiane 
• 1456628-06-0 2-(2-chloroethyl)-2-(4-methoxyphenyl)-1,3-dithiane 
• 1456628-12-8 3-[2-(4-methoxyphenyl)-1,3-dithian-2-yl]propanenitrile 
• 55234-56-5 4-(4-methoxy-phenyl)-4-oxo-butyronitrile 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 26153-41-3 γ-(4-methoxyphenyl)-γ-butyrolactone 

Relevant articles and documents

Synthetic strategy toward γ-KETO NITRILES and their Biocatalytic conversion to asymmetric γ-lactones

Asymmetric γ-hydroxy nitriles are valuable intermediates because hydrolysis of the nitriles can result in an intramolecular cyclization to chiral γ-lactones, which have a variety of biological uses. Starting with an assortment of different aldehydes (alkyl and aryl) a 4-step synthesis of γ-keto nitriles was developed. These prochiral substrates were then screened against a library of ketoreductases for their ability to stereoselectively reduce the carbonyl. Enzymes from the short chain dehydrogenase family showed activity and these enzymatic reactions were scaled up to produce a diverse set of chiral γ-lactones.