14568-13-9Relevant academic research and scientific papers
cis-dibromobis(dimethyl sulfoxide-S)-platinum(II) and trans-bis(dimethyl sulf-oxide-S)diiodoplatinum(II)
Lovqvist
, p. 1921 - 1924 (1996)
The Pt atom has a slightly distorted square-planar coordination in both title compounds, cis-[PtBr2(C2H6OS)2] and trans-[PtI2(C2H6OS)2], with the dimethyl sulfoxide ligands bonded via their S atoms. The bond distances to platinum in the bromo compound are Pt - Br 2.441 (1) and 2.447 (2), and Pt - S 2.254 (2) and 2.245 (2) angstrom, and in the centrosymmetric iodo complex are Pt - I 2.6111 (9) and Pt - S 2.289 (2) angstrom.
Synthesis and studies of anticancer properties of lupane-type triterpenoid derivatives containing a cisplatin fragment
Emmerich, Daniel,Vanchanagiri, Kranthi,Baratto, Leopoldo C.,Schmidt, Harry,Paschke, Reinhard
, p. 460 - 466 (2014)
Both betulinic acid 1 and cisplatin are promising antitumor agents, which induce apoptotic cell death of cancer cells. In the present investigation a new series of betulinic acid-cisplatin conjugates were synthesized and cytotoxicity and selectivity were assessed against five different tumor cell lines. The aim was to combine two structural units, both related with apoptosis induction. The derivatives exerted a dose-dependent antiproliferative action at micromolar concentrations and the effect of these structural variations on anticancer activity was studied and discussed. Several compounds revealed significant antitumor activity, as the most active substance 3-O-acetylbetulinic (2-(2-aminoethyl)aminoethyl)amide (IC50 = 1.30-2.24 μM). Interestingly, Betulinic acid-cisplatin conjugates were less cytotoxic than the precursors.
Hydroxyapatite nanocrystals as a smart, pH sensitive, delivery system for kiteplatin
Lelli, Marco,Roveri, Norberto,Marzano, Cristina,Hoeschele, James D.,Curci, Alessandra,Margiotta, Nicola,Gandin, Valentina,Natile, Giovanni
, p. 13187 - 13195 (2016)
Hydroxyapatite (HA) nanocrystals are important inorganic constituents of biological hard tissues in vertebrates and have been proposed as a bone substitute or a coating material for prostheses in biomedicine. Hydroxyapatite is also amenable for its capacity to bind to a great variety of biomolecules and therapeutic agents. As drug carriers, apatite nanoparticles also have the advantage of pH dependent solubility and low toxicity. Thus HA nanoparticles are negligibly soluble at physiological pH but their dissolution is accelerated at lower pH such as that typically found in the vicinity of tumors. In the present study we have investigated the adsorption on and the release from biomimetic HA nanoparticles of two platinum derivatives of cis-1,4-diaminocyclohexane ([PtX2(cis-1,4-DACH)], X2 = Cl2 (1) and 1,1-cyclobutanedicarboxylate (CBDCA, 2)). The first of the two compounds proved to be active against colon cancer cells also resistant to oxaliplatin. The release has been investigated as a function of pH to mimic the different physiological environments of healthy tissues and tumors, and the in vitro cytotoxicity of the releasates from the HA matrices has been assessed against various human cancer cell lines. The results fully confirmed the potential of 1-loaded HA nanoparticles as bone-specific drug delivery devices.
A cyclometalated trinuclear Ir(iii)/Pt(ii) complex as a luminescent probe for histidine-rich proteins
Das, Bishnu,Gupta, Parna,Kumar, Ravi,Ray, Partho Sarothi,Sarkar, Ankita
, p. 1864 - 1872 (2020)
Organometallic complexes have important application in the field of protein staining, with potential for use in proteomic analysis. The rational synthesis of a trinuclear luminescent organometallic complex with two platinum(ii) centres appended to the cyclometalated ligand of the iridium(iii) centre is reported here. Two di-2-picolylamine groups bonded to the cyclometalated phenyl pyridine moiety provide three coordinating sites to each platinum centre. The replacement of chloride in the fourth coordination site of two square planar platinum metal centres with the imidazole nitrogen or sulphur atom of histidine/cysteine is evident from the change in luminescence intensity upon binding these amino acids. The increase in luminescence emission intensity upon binding of histidine to the organometallic complex allowed it to be used as a protein staining agent. Reversibility of staining upon washing with imidazole enhances the possibility of its application in mass spectrometric analysis.
Multinuclear magnetic resonance characterization and antiproliferative studies of novel dichlorido platinum(II) complexes containing kinetin riboside and 1-β-D-ribofuranosyl-4-(2-pyridyl)-1H-1,2,3-triazole
Jakubowski, Mateusz,?akomska, Iwona,Sitkowski, Jerzy,Pokrywczyńska, Marta,D?browski, Pawe?,Framski, Grzegorz,Ostrowski, Tomasz
, (2020)
The chemical reaction between cis-[PtCl2(dmso)2] and kinetin riboside (KR) or 1-β-D-ribofuranosyl-4-(2-pyridyl)-1H-1,2,3-triazole (PTR) has resulted in two novel platinum(II) complexes being obtained with different compositions of the coordination sphere: cis-[PtCl2(PTR)] (1) and cis-[PtCl2(dmso)(KR)] (2). Based on multinuclear NMR results (1H, 13C, 15N, 195Pt), we have demonstrated that the N-donor ligands PTR and KR are able to coordinate to the Pt(II) ion as bidentate via two nitrogen atoms (N(3) and N(7)) or monodentate via only one nitrogen atom (N(7)), respectively. On the other hand, biological studies showed that the novel platinum(II) complexes exhibit different in vitro cytotoxicity towards A549 (lung carcinoma epithelial cells), T24 (urinary bladder cancer cells) and CRL1872 (malignant melanoma cells). The complex cis-[PtCl2(dmso)(KR)] (2) shows in vitro cytotoxicity against T24 and CRL1872 cell lines (the IC50 parameters amount to 52.2 μM and 21.4 μM, respectively), whereas cis-[PtCl2(PTR)] (1) is not able to inhibit a proliferation of these cells in the range of tested concentrations.
Synthesis, characterization and multi-spectroscopic DNA interaction studies of a new platinum complex containing the drug metformin
Shahabadi, Nahid,Heidari, Leila
, p. 377 - 385 (2014)
A new platinum(II) complex; [Pt(Met)(DMSO)Cl]Cl in which Met = metformin and DMSO: dimethylsulfoxide, was synthesized and characterized by 1H NMR, IR, UV-Vis spectra, molar conductivity and computational methods. Binding interaction of this complex with calf thymus (CT) DNA has been investigated by using absorption, emission, circular dichroism, viscosity measurements, differential pulse voltammetry and cleavage studies by agarose gel electrophoresis. UV-Vis absorption studies showed hyperchromism. CD studies showed less perturbation on the base stacking and helicity bands in the CD spectrum of CT-DNA (B → C structural transition). In fluorimeteric studies, the Pt(II) complex can bind with DNA-NR complex and forms a new non-fluorescence adduct. The anodic peak current in the differential pulse voltammogram of the Pt(II) complex decreased gradually with the addition of DNA. Cleavage experiments showed that the Pt(II) complex does not induce any cleavage under the experimental setup. Finally all results indicated that Pt(II) complex interact with DNA via groove binding mode.
Ambidentate coordination in hydrogen bonded dimethyl sulfoxide, (CH 3)2SO...H3O+, and in dichlorobis(dimethyl sulfoxide) palladium(ii) and platinum(ii) solid solvates, by vibrational and sulfur K-edge X-ray abso
Risberg, Emiliana Damian,Mink, Janos,Abbasi, Alireza,Skripkin, Mikhail Yu.,Hajba, Laszlo,Lindqvist-Reis, Patric,Bencze, Eva,Sandstroem, Magnus
, p. 1328 - 1338 (2009)
The strongly hydrogen bonded species (CH3)2SO... H3O+ formed in concentrated hydrochloric acid displays a new low energy feature in its sulfur K-edge X-ray absorption near edge structure (XANES) spectrum. Densit
Interaction of pyridineplatinum(II) complexes with alkyl sulfoxides
De Vekki
, p. 1238 - 1241 (2008)
Interaction of pyridineplatinum(II) complexes with dimethyl sulfoxide and diethyl sulfoxide is studied by NMR spectroscopy. The interaction products are pyridinesulfoxide and bissulfoxide platinum(II) complexes. Cis-trans isomerization of the products is
8-Mercaptoquinoline as a Ligand for Enhancing the Photocatalytic Activity of Pt(II) Coordination Complexes: Reactions and Mechanistic Insights
Casado-Sánchez, Antonio,Uygur, Mustafa,González-Mu?oz, Daniel,Aguilar-Galindo, Fernando,Nova-Fernández, José Luis,Arranz-Plaza, Judith,Díaz-Tendero, Sergio,Cabrera, Silvia,Manche?o, Olga García,Alemán, José
, p. 6437 - 6447 (2019/05/24)
A family of quinoline-platinum(II) complexes as efficient photocatalysts is presented. Their key characteristic is their easy preparation by coordination of the readily available 8-hydroxy- or 8-thio-quinoline ligands, which are well known for their strong chelating ability to different metal ions. In the different photochemical transformations investigated, such as cross-dehydrogenative coupling, oxidation of arylboronic acids, and asymmetric alkylation of aldehydes, 8-mercaptoquinoline-Pt(II) complex proved to be the most general catalyst. Moreover, quenching experiments showed that, contrary to related methods reported in the literature, these complexes followed an oxidative quenching mechanism in all transformations studied. Besides, simulations performed with high-level ab initio methods of the complexes have helped to understand their photocatalytic activity.
Chelating and Bridging Roles of 2-(2-Pyridyl)benzimidazole and Bis(diphenylphosphino)acetylene in Stabilizing a Cyclic Tetranuclear Platinum(II) Complex
Nabavizadeh, S. Masoud,Niroomand Hosseini, Fatemeh,Niknam, Fatemeh,Hamidizadeh, Peyman,Hoseini, S. Jafar,Ford, Peter C.,Abu-Omar, Mahdi M.
, p. 14617 - 14625 (2019/11/03)
The reaction of complex [Pt(Me)(DMSO)(pbz)], 1, (pbz = 2-(2-pyridyl)benzimidazolate) with [PtMe(Cl)(DMSO)2], B, followed by addition of bis(diphenylphosphino)acetylene (dppac), gave the novel tetranuclear platinum complex [Pt4Me4(μ-dppac)2(pbz)2Cl2], 2, bearing both the pbz and dppac ligands. In this structure, the pbz ligands are both chelating and bridging to stabilize the tetraplatinum framework. The tetranuclear Pt(II) complex was fully characterized by NMR spectroscopy, X-ray crystallography, and mass spectrometry, and its electronic structure was investigated and supported by DFT calculations.
