14580-01-9Relevant academic research and scientific papers
Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases
Rose, Nathan R.,Woon, Esther C. Y.,Tumber, Anthony,Walport, Louise J.,Chowdhury, Rasheduzzaman,Li, Xuan Shirley,King, Oliver N. F.,Lejeune, Clarisse,Ng, Stanley S.,Krojer, Tobias,Chan, Mun Chiang,Rydzik, Anna M.,Hopkinson, Richard J.,Che, Ka Hing,Daniel, Michelle,Strain-Damerell, Claire,Gileadi, Carina,Kochan, Grazyna,Leung, Ivanhoe K. H.,Dunford, James,Yeoh, Kar Kheng,Ratcliffe, Peter J.,Burgess-Brown, Nicola,Von Delft, Frank,Muller, Susanne,Marsden, Brian,Brennan, Paul E.,McDonough, Michael A.,Oppermann, Udo,Klose, Robert J.,Schofield, Christopher J.,Kawamura, Akane
supporting information; experimental part, p. 6639 - 6643 (2012/09/22)
The JmjC oxygenases catalyze the N-demethylation of Nε- methyl lysine residues in histones and are current therapeutic targets. A set of human 2-oxoglutarate analogues were screened using a unified assay platform for JmjC demethylases and related oxygenases. Results led to the finding that daminozide (N-(dimethylamino)succinamic acid, 160 Da), a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily. Kinetic and crystallographic studies reveal that daminozide chelates the active site metal via its hydrazide carbonyl and dimethylamino groups.
Structural Studies of the Reaction Products of Succinic Anhydride and Phenylhydrazine
Ali, Mohd,Khan, Naseem Hasan
, p. 439 - 440 (2007/10/02)
The reaction of succinic anhydride with phenylhydrazine in gl. acetic acid gives a mixture of N-anilinosuccinamic acid (I), hexahydro-2-phenyl-3-phenylhydrazonopyridazine-6-one (II), N,N'-dianilinosuccinamide (III), N-anilino-2,5-diketo-pyrrolidine (IV) and 4,5-dihydro-3-hydroxy-1-phenylpyridazin-6-one (V).Compound II is also obtained via III when I is reacted with phenylhydrazine.
