61152-66-7

Basic information

• Product Name: 1-(phenylamino)pyrrolidine-2,5-dione
• Synonyms: 1-Anilinopyrrolidine-2,5-dione; 2,5-pyrrolidinedione, 1-(phenylamino)-
• CAS NO: 61152-66-7
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.1986
• Mol File: 61152-66-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 313.8°C at 760 mmHg
• Flash Point: 143.6°C
• Density: 1.381g/cm³
• Vapor Pressure: 0.000486mmHg at 25°C
• Refractive Index: 1.67
• CAS DataBase Reference: 1-(phenylamino)pyrrolidine-2,5-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(phenylamino)pyrrolidine-2,5-dione(61152-66-7)
• EPA Substance Registry System: 1-(phenylamino)pyrrolidine-2,5-dione(61152-66-7)

Safety Data

• Hazardous Substances Data: 61152-66-7(Hazardous Substances Data)

Usage

General Description

1-(phenylamino)pyrrolidine-2,5-dione, also known as phenylbutazone, is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and anti-pyretic properties. It is commonly used to relieve the symptoms of arthritis, gout, and other inflammatory conditions. Phenylbutazone works by inhibiting the production of prostaglandins, which are responsible for causing pain and inflammation in the body. It has also been used in veterinary medicine to treat musculoskeletal disorders in horses and other large animals. However, due to its potential for causing serious side effects such as gastrointestinal bleeding and kidney damage, the use of phenylbutazone has been restricted or banned in many countries.

Upstream product

• 108-30-5 succinic acid anhydride 
• 100-63-0 phenylhydrazine 
• 128-08-5 N-Bromosuccinimide 
• 62-53-3 aniline 
• 110-15-6 succinic acid 
• 14580-01-9 4-oxo-4-(2-phenylhydrazinyl)butanoic acid 

Downstream Products

• 107940-76-1 1,1'-(1,2-Diphenyl-1,2-hydrazindiyl)bis(2,5-pyrrolidindion) 

Relevant articles and documents

Simple and efficient synthesis of N-alkyl and N-aryl succinimides in hot water

A new, simple synthesis of succinimides is described. The reactions were carried out under the ultimate green conditions excluding both catalyst and organic solvent by applying simple stirring at 100 °C. A wide variety of N-susbstituted succinimides have been prepared in high yields by using succinic acid and primary amines in hot water. Yield of N-alkyl substituted succinimides were found to be higher than those of N-aryl substituted succinimides.

Preparation of 2,4,6-trichlorophenylhydrazine

Disclosed is a process for the preparation of 2,4,6-trichlorophenylhydrazine by chlorinating the reaction product of phenylhydrazine and a dicarboxylic anhydride to obtain an N-(2,4,6-trichloroanilino)dicarboximide which is reacted with a base capable of liberating 2,4,6-trichlorophenylhydrazine therefrom.

Synthesis and anticonvulsant evaluation of N-aminosuccinimides

Twelve new N-aminosuccinimides were synthesized by the condensation of hydrazines with succinic anhydrides in glacial acetic acid. The compounds were evaluated in the maximal electroshock seizure and subcutaneous pentylenetetrazol seizure threshold tests