145823-43-4

Basic information

• Product Name: diacetyl-4-amino-3-methylphenol
• Synonyms: diacetyl-4-amino-3-methylphenol
• CAS NO: 145823-43-4
• Molecular Weight: 207.229
• Mol File: 145823-43-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: diacetyl-4-amino-3-methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: diacetyl-4-amino-3-methylphenol(145823-43-4)
• EPA Substance Registry System: diacetyl-4-amino-3-methylphenol(145823-43-4)

Safety Data

• Hazardous Substances Data: 145823-43-4(Hazardous Substances Data)

Upstream product

• 2835-99-6 4-amino-3-methylphenol 
• 75-36-5 acetyl chloride 
• 120-66-1 N-(2-methylphenyl)acetamide 
• 64-19-7 acetic acid 
• 39495-15-3 4-acetamido-3-methylphenol 
• 108-24-7 acetic anhydride 

Downstream Products

• 808743-18-2 4-acetamido-3-methyl-5-nitrophenyl acetate 
• 860740-95-0 acetic acid-(4-hydroxy-2-methyl-3,5-dinitro-anilide) 
• 808743-87-5 ethyl 4-{4-[bis(tert-butoxycarbonyl)amino]-3-[(2,4-dichlorobenzyl)amino]-5-methylphenoxy}butanoate 
• 808743-89-7 ethyl 4-(3-[(2,4-dichlorobenzyl)amino]-5-methyl-4-{[(methylamino)carbonothioyl]amino}phenoxy)butanoate 
• 808743-85-3 ethyl 4-{4-[bis(tert-butoxycarbonyl)amino]-3-methyl-5-nitrophenoxy}butanoate 
• 808743-86-4 ethyl 4-{3-amino-4-[bis(tert-butoxycarbonyl)amino]-5-methylphenoxy}butanoate 
• 808743-88-6 ethyl 4-{4-amino-3-[(2,4-dichlorobenzyl)amino]-5-methylphenoxy}butanoate 
• 808743-66-0 ethyl 4-[3-methyl-5-nitro-4-(propionylamino)phenoxy]butanoate 
• 808743-25-1 ethyl 4-[4-(acetylamino)-3-methyl-5-nitrophenoxy]butanoate 
• 808743-26-2 ethyl 4-[4-(acetylamino)-3-amino-5-methylphenoxy]butanoate 
• 808743-59-1 ethyl 4-(4-amino-3-methyl-5-nitrophenoxy)butanoate 
• 808743-60-4 ethyl 4-(3,4-diamino-5-methylphenoxy)butanoate 
• 808743-58-0 4-(4-amino-3-methyl-5-nitrophenoxy)butanoic acid 
• 808743-19-3 4-(acetylamino)-3-amino-5-methylphenyl acetate 

Relevant articles and documents

Synthesis and pharmacological evaluation of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics

We report the optimisation of a series of novel amide-piperidine (piperazine) derivatives using the multiple ligand approach with dopamine and serotonin receptors. Of the derivatives, compound 11 exhibited high affinity for the D2, 5-HT1A, and 5-HT2A receptors, but low affinity for the 5-HT2C and histamine H1 receptors and human ether-a-go-go-related gene (hERG) channels. In vivo, compound 11 reduced apomorphine-induced climbing, MK-801-induced hyperactivity and DOI-induced head twitching without observable catalepsy, even at the highest dose tested. In addition, it exhibited suppression in a CAR test. Furthermore, in a novel object recognition task, it displayed procognition properties. Therefore, compound 11 is a promising candidate multi-target antipsychotic.

Direct acetoxylation and etherification of anilides using phenyliodine bis(trifluoroacetate)

Treatment of various anilides with 1.5 equiv. of phenyliodine bis(trifluoroacetate) (PIFA) and 1.0 equiv. of BF3·OEt 2 in AcOH at room temperature afforded the corresponding para-acetoxylated products with high regioselectivity. In addition, this reaction could be expanded to the etherification of anilides. In the presence of 2.0 equiv. of PIFA and 2.0 equiv. of BF3·OEt2, the reaction of anilides with alcohols provided the corresponding para-etherified products in good yields. The Royal Society of Chemistry 2011.