14584-33-9

Basic information

• Product Name: 4-Fluoro-alpha-methylstyrene
• Synonyms: Styrene, a-(fluoromethyl)- (8CI)
• CAS NO: 14584-33-9
• Molecular Formula: C₉H₉F
• Molecular Weight: 136.17
• Mol File: 14584-33-9.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Fluoro-alpha-methylstyrene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-alpha-methylstyrene(14584-33-9)
• EPA Substance Registry System: 4-Fluoro-alpha-methylstyrene(14584-33-9)

Safety Data

• Hazardous Substances Data: 14584-33-9(Hazardous Substances Data)

Upstream product

• 75-05-8 acetonitrile 
• 98-83-9 isopropenylbenzene 
• 36963-72-1 (3-phenoxyprop-1-en-2-yl)benzene 
• 1286796-32-4 2-phenylprop-2-en-1-yl 4-nitrobenzoate 
• 6006-81-1 3-hydroxy-2-phenylpropene 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 17763-67-6 Phenyl triflate 
• 38858-73-0 1-phenyl-1-trimethylsiloxycyclopropane 
• 77130-15-5 2-phenylallyltrimethylsilane 

Relevant articles and documents

Room-temperature Fluorination of Alkenes with Caesium Fluoroxysulphate

Room-temperature fluorination of 1,1-diphenylethene with caesium fluoroxysulphate resulted in the formation of 2-fluoro-1,1-diphenylethene; norborn-2-ene gave only 7-fluoronortricyclene and 7-syn-fluoronorborn-2-ene, while reactions with various cyclic enol acetates gave α-fluorocycloalkanones in high yield.

Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide

A novel [18F]NF reagent and two novel radiochemical transformations have been developed: [18F]NFSi has been prepared from sodium dibenzenesulfonimide and reacted in the presence of silyl enol ethers and allylsilanes to deliver labell

Biocatalytic Strategy for the Highly Stereoselective Synthesis of CHF2-Containing Trisubstituted Cyclopropanes

The difluoromethyl (CHF2) group has attracted significant attention in drug discovery and development efforts, owing to its ability to serve as fluorinated bioisostere of methyl, hydroxyl, and thiol groups. Herein, we report an efficient biocat

Rhodium catalysed enantioselective synthesis of mono-(halo)-methyl-cyclopropanes

The catalytic asymmetric synthesis of mono-fluoro-, -chloro- and -bromomethyl-1,2-diaryl cyclopropane ester is described. The reaction, using Rh2((S)-BTPCP)4 as a catalyst, allowed the formation of the desired cyclopropanes in good to excellent yields (up to 99%) and excellent diastereoselectivities (up to >20:1) and with a high level of enantioselectivities (up to 98% ee). Finally, the synthetic utility of the chiral cyclopropanes was also demonstrated.

Palladium-catalyzed allylic fluorination

Mild and rapid: The title reaction is presented and its applicability to 18F radiolabeling is demonstrated (see scheme; TBAF=tetra-n- butylammonium fluoride, THF=tetrahydrofuran, dba=dibenzylideneacetone). The use of p-nitrobenzoate as the leaving group is significant to the success of this catalytic organometallic fluorination process. A range of allylic fluorides were synthesized by this method. Copyright