145861-59-2 Usage
General Description
5-NITRO-2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE is a chemical compound with a nitro group attached to a benzimidazole ring, along with a pyridinyl group as a substituent. It is a heterocyclic compound with potential pharmacological applications, including antimicrobial and antiparasitic properties. 5-NITRO-2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE has been evaluated for its potential use as an antibiotic and as an anti-parasitic agent, with research showing promising results in inhibiting the growth of certain bacteria and parasites. The nitro group in this compound has been found to contribute to its antimicrobial activity by disrupting essential cellular processes in microorganisms. Overall, 5-NITRO-2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE shows potential as a candidate for the development of new pharmaceuticals with antimicrobial and antiparasitic properties.
Check Digit Verification of cas no
The CAS Registry Mumber 145861-59-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,8,6 and 1 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 145861-59:
(8*1)+(7*4)+(6*5)+(5*8)+(4*6)+(3*1)+(2*5)+(1*9)=152
152 % 10 = 2
So 145861-59-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H8N4O2/c17-16(18)9-3-4-10-11(6-9)15-12(14-10)8-2-1-5-13-7-8/h1-7H,(H,14,15)
145861-59-2Relevant articles and documents
Design, synthesis and biological evaluation of some novel benzimidazole derivatives for their potential anticonvulsant activity
Jain, Priyal,Sharma, Prakash Kumar,Rajak, Harish,Pawar, Rajesh Singh,Patil, Umesh Kumar,Singour, Pradeep Kumar
, p. 971 - 980 (2010)
Selective GABAA receptor ligands are widely used clinically to reduce the occurrence of convulsions. Hence there is an intense interest in developing new benzimidazole derivatives demonstrating high selectivity and high affinity for GABAA
Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry
He, Yun,Yang, Jun,Wu, Baogen,Robinson, Dale,Sprankle, Kelly,Kung, Pei-Pei,Lowery, Kristin,Mohan,Hofstadler, Steve,Swayze, Eric E.,Griffey, Rich
, p. 695 - 699 (2007/10/03)
A series of novel benzimidazoles were efficiently synthesized using both solution- and solid-phase chemistry. These compounds were found to bind to the bacterial 16S ribosomal RNA A-site with micromolar affinities using unique mass spectrometry-based assays.
Chemistry of 2-substituted benzimidazoles. 1. 5-Amino-2-methyl(aryl, arylalkyl, pyridyl)benzimidazoles
Ambacheu,Pleshakov,Baatkh,Zvolinskii,Kharlamova,Obynochnyi,Prostakov
, p. 421 - 428 (2007/10/03)
A series of 2-substituted benzimidazoles was synthesized. These products were consecutively converted into 5-nitro- and 5-amino-2-substituted benzimidazoles.
