145876-08-0

Basic information

• Product Name: (R)-5-((2S,4S)-2-Benzyloxymethyl-[1,3]dioxolan-4-yl)-3,4-dihydroxy-5H-furan-2-one
• CAS NO: 145876-08-0
• Molecular Weight: 308.288
• Mol File: 145876-08-0.mol

Chemical Properties

• CAS DataBase Reference: (R)-5-((2S,4S)-2-Benzyloxymethyl-[1,3]dioxolan-4-yl)-3,4-dihydroxy-5H-furan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-((2S,4S)-2-Benzyloxymethyl-[1,3]dioxolan-4-yl)-3,4-dihydroxy-5H-furan-2-one(145876-08-0)
• EPA Substance Registry System: (R)-5-((2S,4S)-2-Benzyloxymethyl-[1,3]dioxolan-4-yl)-3,4-dihydroxy-5H-furan-2-one(145876-08-0)

Safety Data

• Hazardous Substances Data: 145876-08-0(Hazardous Substances Data)

Upstream product

• 127657-97-0 2-benzyloxy-1,1-dimethoxyethane 
• 50-81-7 ascorbic acid 

Downstream Products

• 145985-69-9 (2S,4S)-2-((benzyloxy)methyl)-1,3-dioxolane-4-carboxylic acid 
• 192581-99-0 (2S)-2-((benzyloxy)methyl)-1,3-dioxolan-4-yl acetate 
• 154459-77-5 2S-benzyloxymethyl-4S acetoxy-1,3 dioxolane 

Relevant articles and documents

Divergent Asymmetric Syntheses of Dioxolane Nucleoside Analogues

Oxidative degradation of benzyloxymethylacetals derived from D-mannitol or L-ascorbic acid provides dioxolane intermediate 6 and 7 useful in the synthesis of all the stereoisomers of dioxolane nucleoside analogues.

Oxidative Degradation of L-Ascorbic Acid Acetals to 2',3'-Dideoxy-3'-Oxaribofuranosides. Synthesis of Enantiomerically Pure 2',3'-Dideoxy-3'-Oxacytidine Stereoisomers as Potential Antiviral Agents

Enantiomerically pure 2',3'-dideoxy-3'-oxacytidine nucleoside analogues were synthesized from L-ascorbic acid in eight steps and good overall yield.