192581-99-0

Basic information

• Product Name: 1,3-Dioxolan-4-ol, 2-[(phenylmethoxy)methyl]-, acetate, (2S)-
• CAS NO: 192581-99-0
• Molecular Formula: C13H16O5
• Molecular Weight: 252.267
• Mol File: 192581-99-0.mol

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolan-4-ol, 2-[(phenylmethoxy)methyl]-, acetate, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolan-4-ol, 2-[(phenylmethoxy)methyl]-, acetate, (2S)-(192581-99-0)
• EPA Substance Registry System: 1,3-Dioxolan-4-ol, 2-[(phenylmethoxy)methyl]-, acetate, (2S)-(192581-99-0)

Safety Data

• Hazardous Substances Data: 192581-99-0(Hazardous Substances Data)

Upstream product

• 546-67-8 lead(IV) tetraacetate 
• 145985-69-9 (2S,4S)-2-((benzyloxy)methyl)-1,3-dioxolane-4-carboxylic acid 
• 145876-08-0 (R)-5-((2S,4S)-2-Benzyloxymethyl-[1,3]dioxolan-4-yl)-3,4-dihydroxy-5H-furan-2-one 
• 100-39-0 benzyl bromide 
• 127657-97-0 2-benzyloxy-1,1-dimethoxyethane 

Downstream Products

• 153565-51-6 9-((2S,4S)-2-Benzyloxymethyl-[1,3]dioxolan-4-yl)-6-chloro-9H-purin-2-ylamine 
• 153565-50-5 2-Amino-9-((2S,4S)-2-benzyloxymethyl-[1,3]dioxolan-4-yl)-1,9-dihydro-purin-6-one 
• 153565-52-7 9-((2S,4S)-2-Benzyloxymethyl-[1,3]dioxolan-4-yl)-6-chloro-9H-purine 
• 145397-26-8 4-amino-5-fluoro-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)pyrimidin-2(1H)-one 
• 145397-26-8 (+)-(2S,4R)-5-fluoro-1-[2-(hydroxymethyl)-1,3-dioxolan-4-yl]cytosine 
• 145918-75-8 troxacitabine 
• 145416-37-1 (-)-L-α-dioxolane-cytosine 
• 153565-49-2 Diphenyl-carbamic acid 2-acetylamino-9-((2S,4S)-2-benzyloxymethyl-[1,3]dioxolan-4-yl)-9H-purin-6-yl ester 

Relevant articles and documents

DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER

The invention provides compounds of formula (I), wherein: R1 is OR11, or NR5R5'; R2 is H or F; R5 is H, C1-C6alkyl, OH, C(=O)R6, O(C=O)R6 or O(C=O)OR6; R5′ is H or C1-C6alkyl; R6 is C1-C6alkyl or C3-C7cycloalkyl; R13 is H, phenyl, pyridyl, benzyl, indolyl or naphthyl wherein the phenyl, pyridyl, benzyl, indolyl and naphthyl is optionally substituted with 1, 2 or 3 R22; and the other variables are as defined in the claims, which are of use in the treatment of cancer, and related aspects.

Structure-activity relationships among a new class of antiviral heterosubstituted 2',3'-dideoxynucleoside analogues

3'-Oxa-4'-thiocytidine nucleoside analogues 14-17 were prepared from oxathiolanes 10 and 11, and evaluated for activity against HIV-1 and HBV in vitro. The nucleoside analogues were found to possess potent activities against HIV-1 in a panel of cell lines. Compound 16 is moderately active against HBV in 2.2.15 cells.

Oxidative Degradation of L-Ascorbic Acid Acetals to 2',3'-Dideoxy-3'-Oxaribofuranosides. Synthesis of Enantiomerically Pure 2',3'-Dideoxy-3'-Oxacytidine Stereoisomers as Potential Antiviral Agents

Enantiomerically pure 2',3'-dideoxy-3'-oxacytidine nucleoside analogues were synthesized from L-ascorbic acid in eight steps and good overall yield.