1459-48-9

Basic information

• Product Name: 4-(1-ADAMANTYL)ANILINE
• Synonyms: 4-(1-ADAMANTYL)ANILINE;1-(p-Aminophenyl)adamantane;4-(Adamantan-1-yl)phenylamine;Benzenamine,4-tricyclo[3.3.1.13,7]dec-1-yl-
• CAS NO: 1459-48-9
• Molecular Formula: C₁₆H₂₁N
• Molecular Weight: 227.34
• Product Categories: Adamantane derivatives
• Mol File: 1459-48-9.mol
• Article Data: 12

Chemical Properties

• Melting Point: 107-108℃
• Boiling Point: 367.4°C at 760 mmHg
• Flash Point: 154.1°C
• Appearance: /
• Density: 1.132±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 1.37E-05mmHg at 25°C
• Refractive Index: 1.623
• CAS DataBase Reference: 4-(1-ADAMANTYL)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-ADAMANTYL)ANILINE(1459-48-9)
• EPA Substance Registry System: 4-(1-ADAMANTYL)ANILINE(1459-48-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 1459-48-9(Hazardous Substances Data)

Usage

Uses

4-(1-Adamantyl)aniline is used as a reactant in the preparation of pyrroledione derivatives as inhibitors of glycogen synthase kinase-3.

InChI:InChI=1/C16H21N/c17-15-3-1-14(2-4-15)16-8-11-5-12(9-16)7-13(6-11)10-16/h1-4,11-13H,5-10,17H2

Upstream product

• 1459-49-0 1-(4-nitrophenyl)adamantane 
• 71-43-2 benzene 
• 768-95-6 1-adamanthanol 
• 103-84-4 Acetanilid 
• 108-88-3 toluene 
• 175881-22-8 4-(1-adamantyl)benzoic acid chloride 
• 7164-55-8 ethyl 4-(adamantan-1-yl)benzoate 
• 1459-55-8 4-(1-adamantyl)toluene 
• 768-90-1 1-Adamantyl bromide 
• 540-37-4 p-aminoiodobenzene 
• 1247829-32-8 tert-butyl [4-(adamantan-1-yl)phenyl]carbamate 
• 7123-78-6 4-(adamant-1-yl)benzoic acid 
• 780-68-7 1-phenyladamantane 
• 24569-89-9 1,3-dehydroadamantane 

Downstream Products

• 1459-50-3 N-(4-((3r,5r,7r)-adamantan-1-yl)phenyl)acetamide 
• 1247829-35-1 ethyl {[4-(adamantan-1-yl)phenyl]amino}oxoacetate 

Relevant articles and documents

Modes of Micromolar Host-Guest Binding of β-Cyclodextrin Complexes Revealed by NMR Spectroscopy in Salt Water

Multitopic supramolecular guests with finely tuned affinities toward widely explored cucurbit[n]urils (CBs) and cyclodextrins (CDs) have been recently designed and tested as functional components of advanced supramolecular systems. We employed various spa

NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS

The present disclosure compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the TEAD transcription factor, and are useful in the treatment of diseases related to the activity of TEAD transcription factor including, e.g., cancer and other diseases.

4-(1-Adamantyl)phenylalkylamines with potential antiproliferative activity

Background: In our previous publications we have described the synthesis of aminosubstituded diaryl adamantanes and their pharmacological evaluation in vitro and in vivo against many cancer cell lines. More recently, we have reported the synthesis of mono