14590-54-6

Basic information

• Product Name: 1α,2β-Cyclopropanedicarboxylic acid
• Synonyms: (1S)-Cyclopropane-1α,2β-dicarboxylic acid;(1S,2S)-1,2-Cyclopropanedicarboxylic acid;(1S,2S)-1-Methylcyclopropane-1,2-dicarboxylic acid;(1S,2S)-cyclopropane-1,2-dicarboxylic acid
• CAS NO: 14590-54-6
• Molecular Formula: C₅H₆O₄
• Molecular Weight: 130.098
• Mol File: 14590-54-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 168-169 °C
• Boiling Point: 305.8±25.0 °C(Predicted)
• Appearance: /
• Density: 1.673±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Ethanol (Slightly)
• PKA: 3.84±0.11(Predicted)
• CAS DataBase Reference: 1α,2β-Cyclopropanedicarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1α,2β-Cyclopropanedicarboxylic acid(14590-54-6)
• EPA Substance Registry System: 1α,2β-Cyclopropanedicarboxylic acid(14590-54-6)

Safety Data

• Hazardous Substances Data: 14590-54-6(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 14590-54-6 differently. You can refer to the following data:
1. (1S,2S)-cyclopropane-1,2-dicarboxylic acid is an reagent used in the synthesis of bleomycin (B595800), a antitumor and antibiotic agent.
2. (1S,2S)-1,2-Cyclopropanedicarboxylic acid is an reagent used in the synthesis of bleomycin (B595800), a antitumor and antibiotic agent.

Upstream product

• 88335-96-0 (+)-(1S,2S)-cyclopropane-1,2-dicarboxylic acid monomethyl ester 
• 826-35-7 dimethyl trans-1,2-cyclopropanedicarboxylate 
• 3999-55-1 diethyl trans-cyclopropane-1,2-dicarboxylate 
• 35974-55-1 methyl (±)-trans-2-carbamoylcyclopropanecarboxylate 
• 889461-57-8 (+)-(S,S)-cyclopropane-1,2-dicarboxylic acid diethyl ester 
• 13279-88-4 racemic trans-2-methoxycarbonylcyclopropanecarboxylic acid 
• 96149-00-7 (1S,2S)-cyclopropane-1,2-dicarboxylic acid bis-(1R,2S,5R)-(5-isopropyl-2-methyl-cyclohexyl) ester 
• 78392-58-2 (+)-dibornyl fumarate 
• 74-95-3 1,1-dibromomethane 
• 2183-87-1 rac-(1R,2S)-2-ethenylcyclopropane-1-carboxylic acid 
• 88335-87-9 (1S,RS)-cis-2-methoxycarbonyl-cyclopropane-1-carboxylic acid 

Downstream Products

• 781658-85-3 1,2;3,4-(di-O-isopropylidene)-6-O-α-D-galactopyranosyl (1S,2S)-2-(3,4-dichlorobenzoyl)-cyclopropane-1-carboxylate 
• 889461-57-8 (+)-(S,S)-cyclopropane-1,2-dicarboxylic acid diethyl ester 
• 16205-67-7 dimethyl (1S,2S)-cyclopropane-1,2-dicarboxylate 
• 21019-55-6 (+)-diphenyl trans-1,2-cyclopropanedicarboxylate 
• 45718-99-8 (1S,2S)-Cyclopropane-1,2-dicarbonyl dichloride 

Relevant articles and documents

ASYMMETRIC CYCLOPROPANATION OF FUMARATES WITH METHYLENE BROMIDE CATALYZED BY COBALT OR NICKEL COMPLEXES

Highly optically active trans-1,2-cyclopropanedicarboxylic acid derivatives were prepared from chiral fumarates and methylene bromide catalyzed by cobalt(0) or nickel(0) complexes.

COSMETIC USES AND METHODS FOR INDOLINE GRANZYME B INHIBITOR COMPOSITIONS

Cosmetic uses and methods for indoline granzyme B inhibitor compounds in compositions with a cosmetically acceptable carrier. Uses and methods for treating, reducing or inhibiting the appearance of ageing in the skin are provided. Also provided are compositions and formulation for cosmetic uses and methods of maintaining a youthful appearance, reducing an appearance of ageing, inhibiting an appearance of ageing, reducing a rate of an appearance of ageing, reducing a skin inelasticity, reducing a rate of increasing skin inelasticity, maintaining a skin elasticity, and increasing the density of hair follicles of a skin of a subjecl. The uses and methods comprise applying/administering an indoline granzyme B inhibitor to a skin, or a portion of a skin of the subject.

Glycoside derivatives of 2-(3,4-dichlorobenzoyl)-cycopropane-1-carboxylic acid

The compounds of formula I: ???wherein R is a glycoside residue optionally having one or more hydroxy groups alkylated or acylated by C1-C4 alkyl or acyl groups, are long lasting inhibitors of kynurenine 3-monooxygenase (KMO) and potent glutamate (GLU) re