14596-55-5

Basic information

• Product Name: [2-(methylamino)ethyl]phosphonic acid
• CAS NO: 14596-55-5
• Molecular Formula: C₃H₁₀NO₃P
• Molecular Weight: 139.0902
• Mol File: 14596-55-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 321.1°C at 760 mmHg
• Flash Point: 148°C
• Density: 1.311g/cm³
• Vapor Pressure: 6.29E-05mmHg at 25°C
• Refractive Index: 1.468
• CAS DataBase Reference: [2-(methylamino)ethyl]phosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [2-(methylamino)ethyl]phosphonic acid(14596-55-5)
• EPA Substance Registry System: [2-(methylamino)ethyl]phosphonic acid(14596-55-5)

Safety Data

• Hazardous Substances Data: 14596-55-5(Hazardous Substances Data)

Usage

General Description

[2-(methylamino)ethyl]phosphonic acid is a chemical compound with the molecular formula C4H11NO3P. It is also known by the trade name glyphosate. [2-(methylamino)ethyl]phosphonic acid is a phosphonic acid derivative that acts as a broad-spectrum herbicide by inhibiting the enzyme 5-enolpyruvylshikimate-3-phosphate synthase, which is essential for the production of aromatic amino acids in plants. It is widely used in agriculture to control the growth of unwanted plants and weeds. However, there has been controversy and debate surrounding its safety and potential environmental impact, with some studies linking it to health concerns and ecological damage. As a result, the use of [2-(methylamino)ethyl]phosphonic acid has become a topic of significant public and scientific interest.

Upstream product

• 67264-30-6 diethyl 2-(N-methylamino)ethylphosphonate 
• 16672-87-0 2-chloroethylphosphonic acid 
• 593-51-1 methylamine hydrochloride 
• 74-89-5 methylamine 
• 72696-79-8 {2-[(Diethoxy-phosphoryl)-methyl-amino]-ethyl}-phosphonic acid diethyl ester 
• 1606-75-3 (2-oxoethyl)phosphonic acid diethyl ester 

Relevant articles and documents

A new simple route to N-substituted 2-aminoethylphosphonic acids

2-Aminoethylphosphonic acid (AEPA) and its N-substituted compounds were prepared by one step reaction using 2-chloroethylphosphonic acid with ammonia and amines (H2NMe, HNMeMe, HNEtEt, H2NPr-n, H2NCH2ph,H2NCH2CH2NH2 and H2N(C=NH)NH2 in a dilute alkaline solution below 20 °C with simple work- up and easy purification. The reaction was accelerated by catalytic amount of potassium iodide. The yield for the reaction products were 35.6 to 48.6% for the KI absence and 78.2 to 88.0% for the KI presence.

Tanshinone IIA phosphoric acid derivative and synthesis and use thereof as medicine

The invention discloses a tanshinone IIA phosphoric acid derivative and synthesis and use thereof as a medicine for treatment. In particular, the present invention provides a novel derivative shown as a general formula (I) and a pharmaceutically acceptable salt thereof or a pharmaceutical composition containing the novel derivative shown as the general formula (I), and a method for preparing the novel derivative shown as the general formula (I). The invention also discloses use of the novel derivative, the pharmaceutically acceptable salt thereof or the pharmaceutical composition containing the novel derivative in preparation of medicines for treatment of coronary heart disease, angina, myocardial infarction, viral myocarditis, arrhythmia, cerebrovascular disease, hepatitis, pulmonary heart disease, bronchial asthma, cancer, kidney disease, eye disease, thromboangiitis obliterans, hypertension, fractures, burns, surgical operations or behcet ' s syndrome. On the basis of ensurance of the activity of tanshinone IIA, the novel derivative, the water solubility of the pharmaceutically acceptable salt thereof or the pharmaceutical composition containing the novel derivative can be improved. Compared with tanshinone IIA sodium sulfonate, the stability is improved, and because the acidity of the pharmaceutically acceptable salt thereof or the pharmaceutical composition containing the novel derivative is reduced obviously, injection stimulation can be avoided. All substituents of the general formula (I) are as defined in the specification.

SYNTHESES OF D-ERYTHRO-1-DEOXYDIHYDROCERAMIDE-1-SULFONIC ACID AND PHOSPHONOSPHINGOGLYCOLIPID FOUND IN MARINE ORGANISM VIA A COMMON PRECURSOR

D-Erythro-1-deoxydihydroceramide-1-sulfonic acid, isolated from alkali-stable hydrogenated lipids in a non-photosynthetic marine diatom, Nitzschia alba, and (2S,3R)-N-palmitoyl-1-O--β-D-galactopyranosyl>-D-sphingosine, found in marine snail Turbo cornutus were synthesized via a common precursor (10) starting from galactose.