A new simple route to N-substituted 2-aminoethylphosphonic acids

Article abstract of DOI:10.1080/00397919808004835

2-Aminoethylphosphonic acid (AEPA) and its N-substituted compounds were prepared by one step reaction using 2-chloroethylphosphonic acid with ammonia and amines (H₂NMe, HNMeMe, HNEtEt, H₂NPr-n, H₂NCH₂ph,H₂NCH₂CH₂NH₂ and H₂N(C=NH)NH₂ in a dilute alkaline solution below 20 °C with simple work- up and easy purification. The reaction was accelerated by catalytic amount of potassium iodide. The yield for the reaction products were 35.6 to 48.6% for the KI absence and 78.2 to 88.0% for the KI presence.

Full text of DOI:10.1080/00397919808004835

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A New Simple Route
To N-Substituted 2-
Aminoethylphosphonic Acids
Xiangkai Fu a , Chengbin Gong a , Xuebing Ma a
& Shuying Wen a
a College of Chemistry and chemical
Engineering, Southwest-China Normal
University, Chongqing, P.R. China, 400715
Version of record first published: 20 Aug 2006.
To cite this article: Xiangkai Fu , Chengbin Gong , Xuebing Ma & Shuying Wen
(1998): A New Simple Route To N-Substituted 2-Aminoethylphosphonic Acids,
Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 28:14, 2659-2664
To link to this article: http://dx.doi.org/10.1080/00397919808004835
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