145966-59-2

Upstream product

• 100-52-7 benzaldehyde 
• 2543-57-9 1-Dimethylamino-3-butanon 
• 50-00-0 formaldehyd 
• 64-17-5 ethanol 
• 506-59-2 N,N-dimethylammonium chloride 
• 1896-62-4 (E)-benzalacetone 
• 14604-31-0 (E)-1-phenylpent-1-en-4-yn-3-ol 

Downstream Products

• 145966-79-6 5-dimethylamino-1t-phenyl-pent-1-en-3-one-phenylhydrazone; hydrochloride 
• 84175-31-5 diethyl (E)-(3-oxo-5-phenyl-4-pentenyl)phosphonate 

Relevant academic research and scientific papers

Evaluation of Mannich bases and related compounds as inhibitors of mitochondrial function in yeast and inhibition of blood platelet aggregation, blood clotting, and in vitro metabolism of 5 dimethylamino 1 phenyl 1 penten 3 one hydrochloride

5 Dimethylamino 1 phenyl 1 penten 3 one hydrochloride (Ia) and 32 analogs were tested for inhibition of respiratory dependent growth in Saccharomyces cerevisiae. 13 Of the 33 compounds tested appeared to affect mitochondrial function, since the inhibition

Metal-free synthesis of β-aminoketones by the reductive hydroamination of ynones

This study describes a cascade method for the synthesis of β-aminoketones through the reductive hydroamination of alkynes under very mild metal-free conditions. It allows for the rapid conversion of ynones and amines into corresponding β-aminoketones with a broad substrate scope and diverse functionalities. This straightforward and easy-to-handle reaction process can be successfully applied for the synthesis of Proroxan and Propipocaine, offering a potential option for the synthesis of drug molecules with the β-aminoketone skeleton.

Antiviral 1-aryl-5-amino-1-penten-3-ones

Compounds of the formula STR1 wherein R is H, halo, C1-4 alkyl, C1-4 alkoxy, 3,4-methylenedioxy, CF3, NO2, NH2, N(C1-4 alkyl)2, CN, OH, --S(C1-4 alkyl) or --SO2/