145987-17-3

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 33596-66-6 2-(4-methylphenyl)propanal 
• 624-31-7 4-tolyl iodide 
• 105-36-2 ethyl bromoacetate 
• 107-18-6 allyl alcohol 

Downstream Products

• 19876-63-2 4-p-tolyl-valeric acid ethyl ester 
• 26232-97-3 4-p-tolylpentanoic acid 
• 4895-17-4 4-p-tolyl-valeryl chloride 
• 145950-78-3 diazo-5-(4-methylphenyl)-2-hexanone 

Relevant academic research and scientific papers

A novel consecutive three-component Heck-isomerization-Wittig sequence by way of in situ generated aldehydes

A novel consecutive three-component four step synthesis of 5-(hetero)arylpent-2-enoates has been disclosed. Various (hetero)aryl iodides can be coupled with allyl alcohol under Heck conditions to give 3-(hetero)arylpropionaldehyde intermediates, which were transformed without isolation with in situ generated stabilized phosphorus ylides to furnish 5-(hetero)arylpent-2-enoates in moderate to excellent yield. This one-pot procedure circumvents the isolation of sensitive aldehydes and phosphorus ylides as intermediates and finally gives the product isomers with good to excellent E/Z and β/α selectivity. ARKAT-USA, Inc.

Efficient synthesis of (+/-)-ar-himachalene: Applications of chemoselective rhodium-carbenoid reaction with the aromatic nucleus

A practical synthesis of (+/-)-ar-Himachalene is realized utilizing selective rhodium-carbenoid insertion into the aromatic nucleus as a pivotal step.