1461736-27-5Relevant articles and documents
Pyrrolo[2,3-d]pyrimidine synthesis through activation of N-benzyl groups by distal amides
El Kaim, Laurent,Grimaud, Laurence,Wagschal, Simon
supporting information, p. 6883 - 6885 (2013/10/08)
A new activation mode of CH2-benzylamino groups has been observed during the preparation of pyrrolopyrimidines from Ugi-Smiles adducts of hydroxypyrimidines. The cyclization proceeds via a formal deprotonation of the N-benzyl group followed by trapping of the resulting anion by the alkyne moiety. The key role of the vicinal amide function during the process was pointed out.